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 PMID:22911747  

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  2. PMID:22911747

Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.

Céline Douarre | Carole Sourbier | Ilaria Dalla Rosa | Benu Brata Das | Christophe E Redon | Hongliang Zhang | Len Neckers | Yves Pommier
PloS one | 2012

Mitochondria contain their own DNA genome (mtDNA), as well as specific DNA replication and protein synthesis machineries. Relaxation of the circular, double-stranded mtDNA relies on the presence of topoisomerase activity. Three different topoisomerases have been identified in mitochondria: Top1mt, Top3α and a truncated form of Top2β.

Pubmed ID: 22911747

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  • Agency: Intramural NIH HHS, United States

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Zeiss AIM 4.2 SP1 software (tool)

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