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 PMID:33484949  

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  2. PMID:33484949

Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice.

Marine L Croze | Marcus F Flisher | Arthur Guillaume | Caroline Tremblay | Glyn M Noguchi | Sabrina Granziera | Kevin Vivot | Vincent C Castillo | Scott A Campbell | Julien Ghislain | Mark O Huising | Vincent Poitout
Molecular metabolism | 2021

Maintenance of glucose homeostasis requires the precise regulation of hormone secretion from the endocrine pancreas. Free fatty acid receptor 4 (FFAR4/GPR120) is a G protein-coupled receptor whose activation in islets of Langerhans promotes insulin and glucagon secretion and inhibits somatostatin secretion. However, the contribution of individual islet cell types (α, β, and δ cells) to the insulinotropic and glucagonotropic effects of GPR120 remains unclear. As gpr120 mRNA is enriched in somatostatin-secreting δ cells, we hypothesized that GPR120 activation stimulates insulin and glucagon secretion via inhibition of somatostatin release.

Pubmed ID: 33484949

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK110276
  • Agency: NIA NIH HHS, United States
    Id: R25 AG048787
  • Agency: NIGMS NIH HHS, United States
    Id: T32 GM099608

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