Searching the Resource Information Network
Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.
An animal adapts its motor behavior to navigate the external environment. This adaptation depends on proprioception, which provides feedback on an animal's body postures. How proprioception mechanisms interact with motor circuits and contribute to locomotor adaptation remains unclear. Here, we describe and characterize proprioception-mediated homeostatic control of undulatory movement in the roundworm Caenorhabditis elegans. We found that the worm responds to optogenetically or mechanically induced decreases in midbody bending amplitude by increasing its anterior amplitude. Conversely, it responds to increased midbody amplitude by decreasing the anterior amplitude. Using genetics, microfluidic and optogenetic perturbation response analyses, and optical neurophysiology, we elucidated the neural circuit underlying this compensatory postural response. The dopaminergic PDE neurons proprioceptively sense midbody bending and signal to AVK interneurons via the D2-like dopamine receptor DOP-3. The FMRFamide-like neuropeptide FLP-1, released by AVK, regulates SMB head motor neurons to modulate anterior bending. We propose that this homeostatic behavioral control optimizes locomotor efficiency. Our findings demonstrate a mechanism in which proprioception works with dopamine and neuropeptide signaling to mediate motor control, a motif that may be conserved in other animals.
Pubmed ID: 37155851
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Center that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
View all literature mentionsCaenorhabditis elegans with name EMPTY from WB.
View all literature mentionsCaenorhabditis elegans with name del-1(ok150) X. from WB.
View all literature mentionsCaenorhabditis elegans with name trp-2(sy691) III. from WB.
View all literature mentionsCaenorhabditis elegans with name egl-8(md1971) V. from WB.
View all literature mentionsCaenorhabditis elegans with name dop-1(vs100) dop-3(vs106) X. from WB.
View all literature mentionsCaenorhabditis elegans with name cat-2(e1112) II. from WB.
View all literature mentionsCaenorhabditis elegans with name gon-2(q388) I. from WB.
View all literature mentionsCaenorhabditis elegans with name dgk-1(sa748) X. from WB.
View all literature mentionsCaenorhabditis elegans with name flp-1(yn4) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name eat-16(ad702) I. from WB.
View all literature mentionsCaenorhabditis elegans with name arIs37 I; cup-5(ar465) III; dpy-20(e1282) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name gpb-2(sa603) I. from WB.
View all literature mentionsCaenorhabditis elegans with name acd-3(ok1335) X. from WB.
View all literature mentionsCaenorhabditis elegans with name unc-25(e156) III. from WB.
View all literature mentionsCaenorhabditis elegans with name trp-4(sy695) I. from WB.
View all literature mentionsCaenorhabditis elegans with name dop-2(vs105) V from WB.
View all literature mentionsCaenorhabditis elegans with name mec-4(u253) X. from WB.
View all literature mentionsCaenorhabditis elegans with name mec-4(e1611) X. from WB.
View all literature mentionsCaenorhabditis elegans with name npr-1(ky13) X. from WB.
View all literature mentionsCaenorhabditis elegans with name mec-10(e1515) X. from WB.
View all literature mentionsCaenorhabditis elegans with name tdc-1(n3421) II. from WB.
View all literature mentionsCaenorhabditis elegans with name dop-4(tm1392) X. from WB.
View all literature mentionsCaenorhabditis elegans with name dop-2(vs105) V; dop-1(vs100) X. from WB.
View all literature mentionsCaenorhabditis elegans with name egIs1[Pdat-1::gfp] from WB.
View all literature mentionsCaenorhabditis elegans with name tph-1(n4622) II. from WB.
View all literature mentionsCaenorhabditis elegans with name goa-1(sa734) I. from WB.
View all literature mentionsCaenorhabditis elegans with name flp-11(tm2706) X. from WB.
View all literature mentionsCaenorhabditis elegans with name ynIs72. from WB.
View all literature mentionsCaenorhabditis elegans with name dop-2(vs105) V; dop-1(vs100) dop-3(vs106) X. from WB.
View all literature mentionsCaenorhabditis elegans with name dop-1(vs101) X from WB.
View all literature mentionsCaenorhabditis elegans with name egl-30(n686) I. from WB.
View all literature mentionsCaenorhabditis elegans with name dop-2(vs105) V; dop-3(vs106) X. from WB.
View all literature mentionsCaenorhabditis elegans with name trpa-1(ok999) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name dop-3(vs106) X. from WB.
View all literature mentionsCaenorhabditis elegans with name C11E4.4(ok1701) X. from WB.
View all literature mentions