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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Authority Synonyms Record Last Update Mentions Count
DARC - Database for Aligned Ribosomal Complexes
 
Resource Report
Resource Website
10+ mentions
DARC - Database for Aligned Ribosomal Complexes (RRID:SCR_006932) DARC analysis service resource, data analysis service, data or information resource, database, model, production service resource, service resource A database for aligned ribosomal complexes that provides a resource for directly comparing the structures. A collection of files deposited in the RCSB protein data bank and the Electron Microscopy Data Bank have been aligned so as to make direct comparison of the structures possible. An easy-to-use, searchable interface allows users to access and download >130 cryo-EM maps and >300 atomic models in the format of brix and pdb files, respectively. The aligned coordinate system substantially simplifies direct visualization of conformational changes in the ribosome, such as subunit rotation and head-swiveling, as well as direct comparison of bound ligands, such as antibiotics or translation factors. ribosomal complex, cryo-electron microscopy, ribosomal particle, atomic model, ribosome, x-ray crystallography, structure, bio.tools uses: Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB)
uses: Electron Microscopy Data Bank at PDBe (MSD-EBI)
is listed by: Debian
is listed by: bio.tools
has parent organization: Ludwig-Maximilians-University; Munich; Germany
DFG SFB594;
DFG SFB646;
DFG WI3285/1-1
PMID:22009674 biotools:darc_site, nlx_149452 https://bio.tools/darc_site SCR_006932 SciCrunch Registry The DARC site, Database for Aligned Ribosomal Complexes, Database for Aligned Ribosomal Complexes (DARC), DARC site 2026-11-07 12:00:47 27
HTSeq
 
Resource Report
Resource Website
5000+ mentions
HTSeq (RRID:SCR_005514) HTSeq authoring tool, data processing software, software application, software resource, standalone software THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Software Python package that provides infrastructure to process data from high-throughput sequencing assays. While the main purpose of HTSeq is to allow you to write your own analysis scripts, customized to your needs, there are also a couple of stand-alone scripts for common tasks that can be used without any Python knowledge. python, high-throughput sequencing assay, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: European Molecular Biology Laboratory
DOI:10.1093/bioinformatics/btu638 THIS RESOURCE IS NO LONGER IN SERVICE biotools:htseq, OMICS_01053 https://bio.tools/htseq http://www-huber.embl.de/users/anders/HTSeq/, https://sources.debian.org/src/python3-htseq/ SCR_005514 SciCrunch Registry HTSeq: Analysing high-throughput sequencing data with Python 2026-11-07 12:00:46 8618
GeneTalk
 
Resource Report
Resource Website
10+ mentions
GeneTalk (RRID:SCR_005231) GeneTalk blog, community building portal, data or information resource, data repository, database, narrative resource, portal, service resource, storage service resource A web-based tool, knowledgebase and community for analysis and interpretation of human variant files. VCFs (Variant Call Formats) are preprocessed and annotated, you can filter them, access all databases and provide your expertise to the community by creating annotations. sequence variant, annotation, exome sequencing, genetic variant, gene, data sharing, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:22826540 The community can contribute to this resource, Free, (during beta period) OMICS_00270, biotools:genetalk https://bio.tools/genetalk SCR_005231 SciCrunch Registry GeneTalk - The Professional Network and Online Tool for Geneticists 2026-11-07 12:00:46 31
SPM
 
Resource Report
Resource Website
5000+ mentions
Issue
SPM (RRID:SCR_007037) SPM data analysis software, data processing software, image analysis software, software application, software resource Software package for analysis of brain imaging data sequences. Sequences can be a series of images from different cohorts, or time-series from same subject. Current release is designed for analysis of fMRI, PET, SPECT, EEG and MEG. analysis, brain, imaging, data, sequence, fMRI, PET, SPECT, EEG, MEG, bio.tools uses: Neuroimaging Data Model
uses: imcalc: SPM batch image calculator
is used by: rsfMRI_fconn calculation
is used by: Automatic Analysis
is used by: auto_acpc_reorient
is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is listed by: 3DVC
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
is affiliated with: Clinical Toolbox for SPM
is affiliated with: Statistical non-Parametric Mapping
is related to: WFU Biological Parametric Mapping Toolbox
is related to: vis: SPM Visualized Statistics toolbox
is related to: LEAD-DBS
is related to: CCHMC Pediatric Brain Templates
is related to: IBMA toolbox
is related to: ArtRepair for robust fMRI
is related to: ASL data processing tool box
is related to: BrainVISA / Anatomist
is related to: MRIcro Software
is related to: xjView: A Viewing Program For SPM
is related to: BrainMagix SPM Viewer
is related to: MarsBaR region of interest toolbox for SPM
is related to: NIRS-SPM
is related to: SPM SS - fMRI functional localizers
is related to: Wisconsin White Matter Hyperintensities Segmentation Toolbox
is related to: Dementia-specific FDG PET Template for SPM analyses
is related to: SPM Anatomy Toolbox
is related to: MIPAV: Medical Image Processing and Visualization
is related to: MATLAB
is related to: hMRI-toolbox
is related to: Sandwich Estimator Toolbox
has parent organization: University College London; London; United Kingdom
is required by: MRTool
provides: TSDiffAna
has plug in: ICN_Atlas
works with: UManitoba - JHU Functionally Defined Human White Matter Atlas
works with: NIAG Addiction Data
works with: ICN_Atlas
works with: spm_auto_reorient_coregister
works with: Computational Anatomy Toolbox for SPM
works with: FieldTrip
works with: POAS4SPM
Free, Available for download, Freely available biotools:SPM https://github.com/spm/spm12, https://bio.tools/SPM https://www.fil.ion.ucl.ac.uk/spm/ SCR_007037 SciCrunch Registry Statistical Parametric Mapping, SPM5, SPM2, SPM12, Statistical Parametric Mapping Software, SPM99, SPM8, SPM, SPM96 2026-11-07 12:00:37 8748
MUSCLE
 
Resource Report
Resource Website
10000+ mentions
MUSCLE (RRID:SCR_011812) MUSCLE alignment software, analysis service resource, data analysis service, data analysis software, data processing software, image analysis software, production service resource, service resource, software application, software resource Multiple sequence alignment method with reduced time and space complexity.Multiple sequence alignment with high accuracy and high throughput. Data analysis service for multiple sequence comparison by log- expectation. bio.tools is used by: TranslatorX
is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
is related to: PREFAB
has parent organization: European Bioinformatics Institute
PMID:15034147
PMID:15318951
DOI:10.1093/nar/gkh340
biotools:muscle, OMICS_00982 https://bio.tools/muscle, http://www.drive5.com/muscle/, https://www.drive5.com/muscle/manual/, https://www.drive5, http://bioconductor.org/packages/release/bioc/html/muscle.html.com/muscle/manual/install.html, https://sources.debian.org/src/muscle/ SCR_011812 SciCrunch Registry MUltiple Sequence Comparison by Log- Expectation 2026-11-07 12:00:49 17169
neXtProt
 
Resource Report
Resource Website
100+ mentions
neXtProt (RRID:SCR_008911) data or information resource, database, portal, topical portal THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2025. Human protein knowledge platform. Knowledge platform for human proteins selects and filters high throughput data pertinent to human proteins from UniProtKB. Extends UniProtKB/Swiss-Prot annotations for human proteins to include several new data types. Protein, proteomics, sirna, 3d, pathway, variant, protein-protein interaction, protein-drug interaction, bio.tools, FASEB list is listed by: Debian
is listed by: bio.tools
is related to: UniProtKB
has parent organization: SIB Swiss Institute of Bioinformatics
SIB ;
Swiss Commission for Technology and Innovation
PMID:22139911 THIS RESOURCE IS NO LONGER IN SERVICE biotools:nextprot, nlx_151482 https://bio.tools/nextprot SCR_008911 SciCrunch Registry 2026-11-07 12:00:48 177
Bioinformatic Harvester IV (beta) at Karlsruhe Institute of Technology
 
Resource Report
Resource Website
1000+ mentions
Bioinformatic Harvester IV (beta) at Karlsruhe Institute of Technology (RRID:SCR_008017) data acquisition software, data or information resource, data processing software, database, software application, software resource Harvester is a Web-based tool that bulk-collects bioinformatic data on human proteins from various databases and prediction servers. It is a meta search engine for gene and protein information. It searches 16 major databases and prediction servers and combines the results on pregenerated HTML pages. In this way Harvester can provide comprehensive gene-protein information from different servers in a convenient and fast manner. As full text meta search engine, similar to Google trade mark, Harvester allows screening of the whole genome proteome for current protein functions and predictions in a few seconds. With Harvester it is now possible to compare and check the quality of different database entries and prediction algorithms on a single page. Sponsors: This work has been supported by the BMBF with grants 01GR0101 and 01KW0013. function, gene, bioinformatics, data, database, human, meta search engine, prediction, protein, bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
has parent organization: Karlsruhe Institute of Technology; Karlsruhe; Germany
biotools:harvester, nif-0000-10169 https://bio.tools/harvester SCR_008017 SciCrunch Registry Harvester IV 2026-11-07 12:00:34 1480
PLEXdb - Plant Expression Database
 
Resource Report
Resource Website
10+ mentions
PLEXdb - Plant Expression Database (RRID:SCR_006963) PLEXdb analysis service resource, data analysis service, data or information resource, data repository, database, portal, production service resource, service resource, storage service resource, topical portal PLEXdb (Plant Expression Database) is a unified gene expression resource for plants and plant pathogens. PLEXdb is a genotype to phenotype, hypothesis building information warehouse, leveraging highly parallel expression data with seamless portals to related genetic, physical, and pathway data. The integrated tools of PLEXdb allow investigators to use commonalities in plant biology for a comparative approach to functional genomics through use of large-scale expression profiling data sets. gene expression, plant, plant pathogen, genotype, phenotype, genetic, physical, pathway, plant biology, compare, functional genomics, expression profiling, expression atlas, pathogen, genome, anova, cluster, bio.tools is listed by: Debian
is listed by: bio.tools
is related to: FuncExpression
has parent organization: Iowa State University; Iowa; USA
UniNSF DBI-0543441;
NSF IOS-0922746;
USDA 3625-21000-049-00D
PMID:22084198 biotools:plexdb, r3d100011516, nlx_149236 https://bio.tools/plexdb, https://doi.org/10.17616/R39D13 SCR_006963 SciCrunch Registry PLEXdb - Gene expression resources for plants and plant pathogens, Plant Expression Database 2026-11-07 12:00:34 21
PASA
 
Resource Report
Resource Website
1000+ mentions
PASA (RRID:SCR_014656) data analysis software, data processing software, sequence analysis software, software application, software resource Gene structure annotation and analysis tool that uses spliced alignments of expressed transcript sequences to automatically model gene structures. It also incorporates gene structures based on transcript alignments into existing gene structure annotations. It is one component of a larger eukayotic annotation pipeline implemented at the Broad Institute. gene structure, annotation, gene structure analysis tool, spliced alignment, transcript sequence, bio.tools is used by: BRO_annotation
is listed by: Debian
is listed by: bio.tools
DOI:10.1093/nar/gkg770 Available for download biotools:PASA https://bio.tools/PASA SCR_014656 SciCrunch Registry Program to Assemble Spliced Alignments (PASA), Program to Assemble Spliced Alignments 2026-11-07 12:00:44 1123
Molecular Dynamics Workflow (BioKepler)
 
Resource Report
Resource Website
1+ mentions
Molecular Dynamics Workflow (BioKepler) (RRID:SCR_014389) data processing software, software application, software resource, workflow software A workflow for running molecular dynamics simulations. It can be used for all-atom molecular dynamic simulations, which involve five steps of minimization, one step of heating, three steps of equilibration, and one or more instances of production. The input is a set of directories that include the MD simulation input scripts, system topology and coordinate files. Output files are list of plots, simulation trajectories, intermediate files, restart files, and the like. workflow, MD, molecular dynamics, simulation, software, bio.tools is listed by: bio.tools
is listed by: Debian
is related to: bioKepler
has parent organization: University of California at San Diego; California; USA
NIGMS P41GM103426 Requires Linux biotools:ambergpumdsimulation http://nbcr.ucsd.edu/data/downloads/workflows/, https://bio.tools/ambergpumdsimulation SCR_014389 SciCrunch Registry Molecular Dynamics Workflow, AmberGPUMDSimulation, Molecular Dynamics Workflow Software, Amber GPUMD Simulation 2026-11-07 12:00:44 1
PLINK/SEQ
 
Resource Report
Resource Website
50+ mentions
PLINK/SEQ (RRID:SCR_013193) software application, software library, software resource, software toolkit An open-source C/C++ library for working with human genetic variation data. The specific focus is to provide a platform for analytic tool development for variation data from large-scale resequencing projects, particularly whole-exome and whole-genome studies. However, the library could in principle be applied to other types of genetic studies, including whole-genome association studies of common SNPs. (entry from Genetic Analysis Software) gene, genetic, genomic, c/c++, r, macos, linux, bio.tools is listed by: Genetic Analysis Software
is listed by: bio.tools
is listed by: Debian
is related to: PLINK
has parent organization: Harvard University; Cambridge; United States
Open unspecified license nlx_154213, biotools:plink-seq https://bio.tools/plink-seq SCR_013193 SciCrunch Registry 2026-11-07 12:00:18 77
SPEX2
 
Resource Report
Resource Website
1+ mentions
SPEX2 (RRID:SCR_014923) data analysis software, data processing software, sequence analysis software, software application, software resource Automatic software program for profiling spatial gene expression patterns from Fly embryo ISH images. It utilizes image-based genome-scale profiling of whole-body mRNA patterns. software, spatial gene expression, fly, embryo, extraction, mrna, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: Carnegie Mellon University; Pennsylvania; USA
PMID:20529936 biotools:spex2 https://bio.tools/spex2 SCR_014923 SciCrunch Registry 2026-11-07 11:58:19 1
DOGMA
 
Resource Report
Resource Website
100+ mentions
DOGMA (RRID:SCR_015060) software resource, web application Web-based annotation tool for plant chloroplasts and animal mitochondrial genomes. DOGMA allows the use of BLAST searches against a custom database, and conservation of basepairing in the secondary structure of animal mitochondrial tRNAs to identify and annotate genes. chloroplast, mitochondria, genome annotation, bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
PMID:15180927 Freely available biotools:DOGMA https://bio.tools/DOGMA SCR_015060 SciCrunch Registry Dual Organellar GenoMe Annotator, Dual Organellar GenoMe Annotator (DOGMA) 2026-11-07 11:57:59 428
Online Resource for Community Annotation of Eukaryotes
 
Resource Report
Resource Website
10+ mentions
Online Resource for Community Annotation of Eukaryotes (RRID:SCR_014989) OrcAE, ORCAE data or information resource, narrative resource, wiki Online genome annotation tool for validating and correcting gene annotations. OrcAE is community-driven and can be edited by account-holders in the research community. genome annotation, gene validation, community driven, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: Bioinformatics Gent
has parent organization: Ghent University; Ghent; Belgium
has parent organization: VIB; Flanders; Belgium
PMID:23132114 Free, Account required, The research community can contribute to this resource biotools:orcae https://bio.tools/orcae SCR_014989 SciCrunch Registry Online Resource for Community Annotation of Eukaryotes (OrcAE) 2026-11-07 11:58:23 17
SeaView
 
Resource Report
Resource Website
1000+ mentions
SeaView (RRID:SCR_015059) data analysis software, data processing software, data visualization software, sequence analysis software, software application, software resource Graphical user interface for multiple sequence alignment and molecular phylogeny. SeaView also generates phylogenetic trees. sequence alignment, molecular phylogeny, phylogenetic tree, bio.tools is listed by: Debian
is listed by: bio.tools
is listed by: OMICtools
PMID:19854763
DOI:10.1093/molbev/msp259
Free, Available for download OMICS_08908, biotools:seaview https://bio.tools/seaview, https://sources.debian.org/src/seaview/ SCR_015059 SciCrunch Registry 2026-11-07 11:58:22 1817
MeroX
 
Resource Report
Resource Website
50+ mentions
MeroX (RRID:SCR_014956) data analysis software, data processing software, sequence analysis software, software application, software resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 29,2023. Software tool for the analysis of cross-linking/mass spectrometry datasets using MS-cleavable cross-linkers. MeroX is specialized for MS/MS-cleavable cross linking reagents and identifies the specific fragmentation products of the cleavable cross links. sequence analysis software, cross linking, mass spectrometry, MS cleavage, fragmentation, cleavable cross link, bio.tools is listed by: Debian
is listed by: bio.tools
is related to: StavroX
PMID:25261217 THIS RESOURCE IS NO LONGER IN SERVICE BioTools:MeroX, biotools:MeroX https://bio.tools/MeroX, https://bio.tools/MeroX, https://bio.tools/MeroX SCR_014956 SciCrunch Registry 2026-11-07 11:58:23 74
BUSCO
 
Resource Report
Resource Website
5000+ mentions
BUSCO (RRID:SCR_015008) algorithm resource, data analysis software, data processing software, software application, software resource Software tool to quantitatively measure genome assembly and annotation completeness based on evolutionarily informed expectations of gene content. genome assembly, annotation completeness, quantitative method, bio.tools is used by: rnaQUAST
is recommended by: CEGMA
is listed by: Debian
is listed by: bio.tools
is related to: CEGMA
works with: BUSCOMP
Marie Curie International Outgoing Fellowship ;
Swiss National Science Foundation
DOI:10.1093/bioinformatics/btv351 Free, Available for download, Freely available biotools:busco https://gitlab.com/ezlab/busco, https://bio.tools/busco, https://sources.debian.org/src/busco/ SCR_015008 SciCrunch Registry BUSCO v2, Benchmarking Universal Single-Copy Orthologs (BUSCO), Benchmarking Universal Single-Copy Orthologs, BUSCO v1 2026-11-07 11:58:07 8320
LTR_Finder
 
Resource Report
Resource Website
500+ mentions
LTR_Finder (RRID:SCR_015247) analysis service resource, data access protocol, production service resource, service resource, software resource, web service Web software capable of scanning large-scale sequences for full-length LTR retrotranspsons., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. Long Terminal Repeat retrotransposons, Long Terminal Repeat, retrotransposon prediction, genome sequences, LTR prediction, LTR structure prediction, DNA sequence, biotools is listed by: Debian
is listed by: bio.tools
Fudan University ;
Shanghai ;
China
PMID:17485477 THIS RESOURCE IS NO LONGER IN SERVICE SCR_020944, biotools:ltr_finder https://bio.tools/ltr_finder SCR_015247 SciCrunch Registry LTR Finder 2026-11-07 11:58:24 807
HISAT2
 
Resource Report
Resource Website
10000+ mentions
HISAT2 (RRID:SCR_015530) data analysis software, data processing software, sequence analysis software, software application, software resource, source code Graph-based alignment of next generation sequencing reads to a population of genomes. alignment program, mapping reads, population genomics, human genome, bio.tools is used by: Fcirc
is listed by: Debian
is listed by: bio.tools
is related to: TopHat
has parent organization: Johns Hopkins University; Maryland; USA
is required by: SL-quant
is hosted by: GitHub
NLM R01-LM06845;
NIGMS R01-GM083873;
NSF CCF-0347992
PMID:25751142
DOI:10.1038/s41587-019-0201-4
Available for download OMICS_07225, biotools:hisat2 https://github.com/infphilo/hisat2, https://bio.tools/hisat2, https://sources.debian.org/src/hisat2/ SCR_015530 SciCrunch Registry HISAT 2026-11-07 11:58:27 20753
primers4clades
 
Resource Report
Resource Website
1+ mentions
primers4clades (RRID:SCR_015714) software resource, web application Web application for the design of PCR primers for cross-species amplification of novel sequences from metagenomic DNA or from uncharacterized organisms belonging to user-specified phylogenetic lineages. It implements an extended CODEHOP strategy and evaluates thermodynamic properties of the oligonucleotide pairs. pcr primer, metagenomic dna, phylogenetic lineage, primer, clade, bio.tools is listed by: Debian
is listed by: bio.tools
DGAPA IN201806-2;
CONACyT-Mexico P1-60071;
CSIC 200720I038
PMID:19465390 Freely available, Free for academic use, Tutorial available biotools:primers4clades http://maya.ccg.unam.mx/primers4clades, https://bio.tools/primers4clades SCR_015714 SciCrunch Registry 2026-11-07 11:58:14 2

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