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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
L2L Microarray Analysis Tool
 
Resource Report
Resource Website
1+ mentions
L2L Microarray Analysis Tool (RRID:SCR_013440) L2L analysis service resource, data analysis service, data analysis software, data or information resource, data processing software, data repository, database, production service resource, service resource, software application, software resource, storage service resource THIS RESOURCE IS NO LONGER IN SERVICE, documented May 10, 2017. A pilot effort that has developed a centralized, web-based biospecimen locator that presents biospecimens collected and stored at participating Arizona hospitals and biospecimen banks, which are available for acquisition and use by researchers. Researchers may use this site to browse, search and request biospecimens to use in qualified studies. The development of the ABL was guided by the Arizona Biospecimen Consortium (ABC), a consortium of hospitals and medical centers in the Phoenix area, and is now being piloted by this Consortium under the direction of ABRC. You may browse by type (cells, fluid, molecular, tissue) or disease. Common data elements decided by the ABC Standards Committee, based on data elements on the National Cancer Institute''s (NCI''s) Common Biorepository Model (CBM), are displayed. These describe the minimum set of data elements that the NCI determined were most important for a researcher to see about a biospecimen. The ABL currently does not display information on whether or not clinical data is available to accompany the biospecimens. However, a requester has the ability to solicit clinical data in the request. Once a request is approved, the biospecimen provider will contact the requester to discuss the request (and the requester''s questions) before finalizing the invoice and shipment. The ABL is available to the public to browse. In order to request biospecimens from the ABL, the researcher will be required to submit the requested required information. Upon submission of the information, shipment of the requested biospecimen(s) will be dependent on the scientific and institutional review approval. Account required. Registration is open to everyone.. Documented on August 26, 2019.

Database of published microarray gene expression data, and a software tool for comparing that published data to a user''''s own microarray results. It is very simple to use - all you need is a web browser and a list of the probes that went up or down in your experiment. If you find L2L useful please consider contributing your published data to the L2L Microarray Database in the form of list files. L2L finds true biological patterns in gene expression data by systematically comparing your own list of genes to lists of genes that have been experimentally determined to be co-expressed in response to a particular stimulus - in other words, published lists of microarray results. The patterns it finds can point to the underlying disease process or affected molecular function that actually generated the observed changed in gene expression. Its insights are far more systematic than critical gene analyses, and more biologically relevant than pure Gene Ontology-based analyses. The publications included in the L2L MDB initially reflected topics thought to be related to Cockayne syndrome: aging, cancer, and DNA damage. Since then, the scope of the publications included has expanded considerably, to include chromatin structure, immune and inflammatory mediators, the hypoxic response, adipogenesis, growth factors, hormones, cell cycle regulators, and others. Despite the parochial origins of the database, the wide range of topics covered will make L2L of general interest to any investigator using microarrays to study human biology. In addition to the L2L Microarray Database, L2L contains three sets of lists derived from Gene Ontology categories: Biological Process, Cellular Component, and Molecular Function. As with the L2L MDB, each GO sub-category is represented by a text file that contains annotation information and a list of the HUGO symbols of the genes assigned to that sub-category or any of its descendants. You don''''t need to download L2L to use it to analyze your microarray data. There is an easy-to-use web-based analysis tool, and you have the option of downloading your results so you can view them at any time on your own computer, using any web browser. However, if you prefer, the entire L2L project, and all of its components, can be downloaded from the download page. Platform: Online tool, Windows compatible, Mac OS X compatible, Linux compatible, Unix compatible
microarray, gene expression, adipogenesis, biological, biological process, cancer, cell cycle regulator, cellular component, chromatin, cockayne syndrome, dna damage, growth factor, hormone, human biology, hypoxic response, immune mediator, inflammatory mediator, molecular function, molecular neuroanatomy resource, adipocyte, development, hypoxia, immune, inflammation, metabolism, mitogen, neuro, rna, vascular, transcription, tissue, splicing, mouse, human, rat, source code, statistical analysis, gene, chromatin structure is listed by: Gene Ontology Tools
is related to: Gene Ontology
has parent organization: University of Washington; Seattle; USA
Cockayne syndrome, DNA damage, Other, Aging, Cancer Cora May Poncin Foundation ;
NIGMS GM41624
PMID:16168088 THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-10463 http://depts.washington.edu/l2l/about.html SCR_013440 L2L Microarray Database, L2L Microarray Analysis Tool: A simple tool for discovering the hidden biological significance in microarray expression data, L2L MDB 2026-09-12 12:58:03 1
HOMER
 
Resource Report
Resource Website
5000+ mentions
HOMER (RRID:SCR_010881) HOMER data analysis software, data processing software, sequence analysis software, software application, software resource Software tools for Motif Discovery and next-gen sequencing analysis. Used for analyzing ChIP-Seq, GRO-Seq, RNA-Seq, DNase-Seq, Hi-C and numerous other types of functional genomics sequencing data sets. Collection of command line programs for unix style operating systems written in Perl and C++. motif, discovery, next, generation, sequencing, analysis, genomic, data is listed by: OMICtools
is related to: findMotif.pl
has parent organization: University of California at San Diego; California; USA
Foundation Leducq Transatlantic Network Grant ;
NCI CA52599;
NIDDK DK063491;
NIGMS P50 GM081892;
NIH HC088093;
NURSA consortium grant
PMID:20513432 OMICS_00483 http://biowhat.ucsd.edu/homer/index.html SCR_010881 HOMER, Hypergeometric Optimization of Motif EnRichment, Homer, Homer v4.5 2026-09-12 12:57:25 5929
SimTKCore
 
Resource Report
Resource Website
SimTKCore (RRID:SCR_008268) SimTKCore simulation software, software application, software resource SimTK Core is one of the two packages that together constitute SimTK, the biosimulation toolkit from the Simbios Center. The other major component of SimTK is OpenMM which is packaged separately. This SimTK Core project collects together all the binaries needed for the various SimTK Core subprojects. These include Simbody, Molmodel, Simmath (including Ipopt), Simmatrix, CPodes, SimTKcommon, and Lapack. See the individual projects for descriptions. SimTK brings together in a robust, convenient, open source form the collection of highly-specialized technologies necessary to building successful physics-based simulations of biological structures. These include: strict adherence to an important set of abstractions and guiding principles, robust, high-performance numerical methods, support for developing and sharing physics-based models, and careful software engineering. Accessible High Performance Computing We believe that a primary concern of simulation scientists is performance, that is, speed of computation. We seek to build valid, approximate models using classical physics in order to achieve reasonable run times for our computational studies, so that we can hope to learn something interesting before retirement. In the choice of SimTK technologies, we are focused on achieving the best possible performance on hardware that most researchers actually have. In today''s practice, that means commodity multiprocessors and small clusters. The difference in performance between the best methods and the do-it-yourself techniques most people use can be astoundingeasily an order of magnitude or more. The growing set of SimTK Core libraries seeks to provide the best implementation of the best-known methods for widely used computations such as: Linear algebra, numerical integration and Monte Carlo sampling, multibody (internal coordinate) dynamics, molecular force field evaluation, nonlinear root finding and optimization. All SimTK Core software is in the form of C++ APIs, is thread-safe, and quietly exploits multiple CPUs when they are present. The resulting pre-built binaries are available for download and immediate use. Audience: Biosimulation application programmers interested in including robust, high-performance physics-based simulation in their domain-specific applications. computational algorithm, high-performance, linear algebra, numerical integration, numerical method, optimization, monte carlo sampling, multibody dynamics, molecular force field evaluation, nonlinear root finding, optimizing, cpodes, simbody, ipopt, molmodel, mit license, linux, mac os x, windows is listed by: Biositemaps
has parent organization: Stanford University; Stanford; California
has parent organization: Simtk.org
NIGMS U54 GM072970 PMID:20107615 nif-0000-23310 SCR_008268 2026-09-12 12:57:01 0
Hippocampal Slice Wave Animations
 
Resource Report
Resource Website
Hippocampal Slice Wave Animations (RRID:SCR_008372) animation software, data or information resource, data processing software, data visualization software, portal, resource, simulation software, software application, software resource, topical portal THIS RESOURCE IS NO LONGER IN SERVICE, documented on January 29, 2013. Supplemental data for the paper Changes in mitochondrial function resulting from synaptic activity in the rat hippocampal slice, by Vytautas P. Bindokas, Chong C. Lee, William F. Colmers, and Richard J. Miller that appears in the Journal of Neuroscience June 15, 1998. You can view digital movies of changes in fluorescence intensity by clicking on the title of interest. animation, hippocampal, hippocampus, mitochondrial, movie, neuroscience, rat, slice, wave MRC of Canada MT10520;
NIDA DA02575;
NIDA DA02121;
NIMH MH40165;
NIDDK DK42086;
NIDDK DK44840;
NINDS NS-33502;
NIGMS 5T32GM07151-22;
NICHD HD07009
PMID:9614233 THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-25609 SCR_008372 GIF Animations 2026-09-12 12:57:03 0
MODELLER
 
Resource Report
Resource Website
5000+ mentions
MODELLER (RRID:SCR_008395) data or information resource, portal, simulation software, software application, software resource, topical portal Software tool as Program for Comparative Protein Structure Modelling by Satisfaction of Spatial Restraints. Used for homology or comparative modeling of protein three dimensional structures. User provides alignment of sequence to be modeled with known related structures and MODELLER automatically calculates model containing all non hydrogen atoms. comparative, protein, structure, modelling, satisfaction, spatial, restrain, homology, 3D, alignment, sequence, hydrogen, atom, cluster is listed by: SoftCite
has parent organization: University of California at San Francisco; California; USA
IBM ;
Intel ;
NIGMS P01 GM71790;
NIGMS R01 GM54762;
NIGMS U54 GM62529;
NIH P01 A135707;
Sandler Family Supporting Foundation
Restricted nif-0000-30054 SCR_008395 2026-09-12 12:57:03 5873
HISAT2
 
Resource Report
Resource Website
10000+ mentions
HISAT2 (RRID:SCR_015530) data analysis software, data processing software, sequence analysis software, software application, software resource, source code Graph-based alignment of next generation sequencing reads to a population of genomes. alignment program, mapping reads, population genomics, human genome, bio.tools is used by: Fcirc
is listed by: Debian
is listed by: bio.tools
is related to: TopHat
has parent organization: Johns Hopkins University; Maryland; USA
is required by: SL-quant
is hosted by: GitHub
NLM R01-LM06845;
NIGMS R01-GM083873;
NSF CCF-0347992
PMID:25751142
DOI:10.1038/s41587-019-0201-4
Available for download OMICS_07225, biotools:hisat2 https://github.com/infphilo/hisat2, https://bio.tools/hisat2, https://sources.debian.org/src/hisat2/ SCR_015530 HISAT 2026-09-12 12:58:27 20753
GenePattern Notebook
 
Resource Report
Resource Website
1+ mentions
GenePattern Notebook (RRID:SCR_015699) electronic laboratory notebook, software application, software resource, systems interoperability software, web application Interactive analysis notebook environment that streamlines genomics research by interleaving text, multimedia, and executable code into unified, sharable, reproducible “research narratives.” It integrates the dynamic capabilities of notebook systems with an investigator-focused, simple interface that provides access to hundreds of genomic tools without the need to write code. gene, genomics research, research narrative, notebook system, analysis notebook, bio.tools is listed by: bio.tools
is listed by: Debian
is affiliated with: GenePattern
NIGMS R01-GM074024;
NCI U24-CA194107
PMID:28822753 Open Source, Free, Available for download, Account required biotools:GenePattern_notebook https://bio.tools/GenePattern_notebook SCR_015699 GenePattern Notebook environment 2026-09-12 12:58:29 3
UCSF ChimeraX
 
Resource Report
Resource Website
1000+ mentions
UCSF ChimeraX (RRID:SCR_015872) 3d visualization software, 4d visualization software, data processing software, data visualization software, software application, software resource Software for 3D/4D image reconstruction. UCSF ChimeraX is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. 3d, 4d, image reconstruction, molecular visualization, biocomputing, informatics, rbvi, ucsf, chimera is related to: UCSF Chimera
is related to: UCSF Chimera
has parent organization: University of California at San Francisco; California; USA
has plug in: ISOLDE
NIGMS P41 GM103311 SCR_015872 ChimeraX 2026-09-12 12:58:32 2366
iTools
 
Resource Report
Resource Website
50+ mentions
iTools (RRID:SCR_009626) iTools data access protocol, data or information resource, data repository, database, service resource, software repository, software resource, storage service resource, web service An infrastructure for managing of diverse computational biology resources - data, software tools and web-services. The iTools design, implementation and meta-data content reflect the broad NCBC needs and expertise (www.NCBCs.org). computational neuroscience, data, experiment control, hardware, imaging genomics, information specification, java, loni pipeline, model, ontology, os independent, metadata is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is related to: National Centers for Biomedical Computing
has parent organization: Laboratory of Neuro Imaging
NIH Roadmap for Medical Research ;
NCRR U54-RR021813;
NIDA U54-DA021519;
NCI U54-CA121852;
NHGRI U54-HG004028;
NIGMS U54-GM072970;
NIBIB U54-EB005149;
NLM U54-LM008748
PMID:18509477 GNU Lesser General Public License nlx_155852 http://www.nitrc.org/projects/itools, http://www.loni.usc.edu/research/software http://itools.loni.ucla.edu/ SCR_009626 ITools Resourceome, NCBC iTools 2026-09-12 12:57:14 53
WEBLOGO
 
Resource Report
Resource Website
1000+ mentions
WEBLOGO (RRID:SCR_010236) data access protocol, service resource, software resource, web service Web application to generate sequence logos, graphical representations of patterns within multiple sequence alignment. Designed to make generation of sequence logos easy. Sequence logo generator. Generate sequence logo, pattern graphical representation, multiple sequence alignment, sequence logo generator, amino acid sequence alignment, nucleic acid sequence alignment, sequence alignment representation, bio.tools is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
has parent organization: University of California at Berkeley; Berkeley; USA
NHGRI K22 HG00056;
NIGMS P50 GM62412;
Searle Scholars program
PMID:15173120 Free, Available for download, Freely available nlx_156853, biotools:weblogo_3 http://weblogo.threeplusone.com/, https://bio.tools/weblogo_3 SCR_010236 WebLogo Version 2.8.2, WebLogo3, WebLogo 2026-09-12 12:57:16 3980
MolProbity
 
Resource Report
Resource Website
5000+ mentions
MolProbity (RRID:SCR_014226) software resource, web application A structure-validation web application which provides an expert-system consultation about the accuracy of a macromolecular structure model, diagnosing local problems and enabling their correction. MolProbity works best as an active validation tool (used as soon as a model is available and during each rebuild/refine loop) and when used for protein and RNA crystal structures, but it may also work well for DNA, ligands and NMR ensembles. It produces coordinates, graphics, and numerical evaluations that integrate with either manual or automated use in systems such as PHENIX, KiNG, or Coot. web application, consultation, macromolecular structure, structure validation, macromolecular crystallography is listed by: SoftCite
is related to: Phenix
is related to: Coot
has parent organization: Duke University; North Carolina; USA
Howard Hughes Medical Institute Predoctoral Fellowship ;
NIGMS GM-15000;
NIGMS GM-61302
DOI:10.1107/S0907444909042073 Acknowledgement requested, Requires Java and Javascript https://www.phenix-online.org/documentation/reference/molprobity_tool.html SCR_014226 2026-09-12 12:58:14 6711
Northwestern University Schizophrenia Data and Software Tool (NUSDAST)
 
Resource Report
Resource Website
Northwestern University Schizophrenia Data and Software Tool (NUSDAST) (RRID:SCR_014153) NUSDAT data or information resource, database, image collection A repository of schizophrenia neuroimaging data collected from over 450 individuals with schizophrenia, healthy controls and their respective siblings, most with 2-year longitudinal follow-up. The data include neuroimaging data, cognitive data, clinical data, and genetic data. database, neuroimaging, clinical, cognitive, genetic, schizophrenia, longitudinal uses: CAWorks
is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
has parent organization: Northwestern University; Illinois; USA
Schizophrenia NIMH 1R01 MH084803;
NIMH 1U01 MH097435;
NIMH P50 MH071616;
NIMH R01 MH056584;
NCRR P41 RR15241;
NIGMS U24 GM104203;
NIH Bio-Informatics Research Network Coordinating Center
Available to the research community SCR_014153 Northwestern University Schizophrenia Data and Software Tool 2026-09-12 12:58:13 0
I-TASSER
 
Resource Report
Resource Website
1000+ mentions
I-TASSER (RRID:SCR_014627) data analysis software, data processing software, software application, software resource Web server as integrated platform for automated protein structure and function prediction. Used for protein 3D structure prediction. Resource for automated protein structure prediction and structure-based function annotation. Automated prediction, protein structure prediction, protein function prediction, protein 3D structure, amino acid sequence, alignment, simulation, 3D atomic model, protein, bio.tools is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
has parent organization: University of Michigan; Ann Arbor; USA
has parent organization: University of Kansas; Kansas; USA
NIGMS GM083107;
NIGMS GM084222
DOI:10.1186/1471-2105-9-40
DOI:10.1093/nar/gkv342
PMID:20360767
PMID:18215316
Free, Available for download, Freely available biotools:i-tasser, SCR_018803 https://bio.tools/i-tasser SCR_014627 Iterative Threading Assembly Refinement, Iterative Threading ASSEmbly Refinement 2026-09-12 12:58:19 3874
libRoadRunner
 
Resource Report
Resource Website
10+ mentions
libRoadRunner (RRID:SCR_014763) simulation software, software application, software resource Simulation engine for systems and synthetic biology to be used with other software applications. It retains the original functionality of RoadRunner but has changes in performance, back-end design, event handling, new C++ API, and stochastic simulation support. simulation engine, simulation software, road runner, roadrunner, systems biology, synthetic biology is listed by: Debian
is listed by: OMICtools
NIGMS GM081070 DOI:10.1093/bioinformatics/btv363 Open source, Available for download OMICS_09368 https://sources.debian.org/src/libroadrunner-dev/ SCR_014763 2026-09-12 12:58:21 11
NMRbox
 
Resource Report
Resource Website
50+ mentions
NMRbox (RRID:SCR_014827) software resource, software toolkit, web application Computing platform for biomolecular NMR available to not-for-profit or government users. It consists of a virtual machine (VM) provisioned with dozens of widely-used NMR software packages, and is available as a cloud-based Platform-as-a-Service (PaaS) or as a downloadable VM for local execution. Nuclear Magnetic Resonance, nmr, spectra, computing platform, platform, virtual machine, cloud, software toolbox NIGMS P41GM111135 Account required SCR_014827 , Nuclear Magnetic Resonance box, NMRbox.org 2026-09-12 12:58:22 92
Brain Imaging Data Structure (BIDs)
 
Resource Report
Resource Website
100+ mentions
Brain Imaging Data Structure (BIDs) (RRID:SCR_016124) BIDS data or information resource, narrative resource, portal, standard specification Standard specification for organizing and describing outputs of neuroimaging experiments. Used to organize and describe neuroimaging and behavioral data by neuroscientific community as standard to organize and share data. BIDS prescribes file naming conventions and folder structure to store data in set of already existing file formats. Provides standardized templates to store associated metadata in form of Javascript Object Notation (JSON) and tab-separated value (TSV) files. Facilitates data sharing, metadata querying, and enables automatic data analysis pipelines. System to curate, aggregate, and annotate neuroimaging databases. Intended for magnetic resonance imaging data, magnetoencephalography data, electroencephalography data, and intracranial encephalography data. Data storing structure, neuroimaging, standardized template, data sharing, MRI data, MEG data, EEG data, iEEG data, FASEB list is used by: OpenNeuro
is used by: SPARC Portal
is used by: SPARC Data Standard
is listed by: FAIRsharing
is related to: BIDS-Matlab
is related to: NiPoppy
works with: MNE-BIDS
European Regional Development Fund ;
German federal state of Sachsen-Anhalt ;
International Neuroinformatics Coordinating Facility ;
Laura and John Arnold Foundation ;
Medical Research Council United Kingdom ;
NIAAA U01 AA021697;
NIGMS P20 GM103472;
NIMH Intramural Research Program ;
NSF 1429999;
Wellcome Trust
PMID:27326542
PMID:29917016
PMID:31239435
PMID:31239438
PMID:37744469
Free, Freely available https://bids-specification.readthedocs.io/en/stable/, https://doi.org/10.25504/FAIRsharing.rd1j6t SCR_016124 Brain Imaging Data Structure, BIDS, Brain Imaging Data Structure (BIDS), Brain Imaging Data Structure v1.4.0 2026-09-12 12:58:35 235
SV-plaudit
 
Resource Report
Resource Website
1+ mentions
SV-plaudit (RRID:SCR_016285) data analysis software, data processing software, image analysis software, software application, software resource Software for rapidly curating structural variant (SVs) predictions. SV-plaudit provides a pipeline for creating image views of genomic intervals, automatically storing them in the cloud, deploying a website to view/score them, and retrieving scores for analysis. genomics, structural, variants, visualization, manual, curation, prediction, image, alignment NCI U24 CA209999;
NHGRI K99 HG009532;
NHGRI R01 HG006693;
NIGMS R01 GM124355
Free, Available for download SCR_016285 2026-09-12 12:58:37 2
star-for-criu
 
Resource Report
Resource Website
1+ mentions
star-for-criu (RRID:SCR_016294) alignment software, data processing software, image analysis software, software application, software resource Software as an Hot Start software container for STAR alignment using CRIU (Checkpoint Restore in Userspace) tool to freeze the running container. Can be deployed to align RNA sequencing data. Used in the processing of biomedical big data for better reproducibility and reliability. hot, start, container, star, aligner, sequencing, data, processing, biomedical, cloud, reproducibility, RNA, analysis, computing, environment is related to: Systems Transcriptional Activity Reconstruction AMEDD Advanced Medical Technology Initiative ;
NHLBI U54 HL127624;
NIGMS R01 GM126019
Free, Freely available, Available for download https://github.com/paizhang/Hotstarting-For-STAR-Alignment SCR_016294 2026-09-12 12:58:37 1
MotionCor2
 
Resource Report
Resource Website
100+ mentions
MotionCor2 (RRID:SCR_016499) data analysis software, data processing software, software application, software resource Software tool for anisotropic correction of beam-induced motion for improved cryo-electron microscopy. Used to describe the sample motion as a local deformation that varies smoothly throughout the exposure. A program running on Linux. anisotropic, correction, beam, induced, motion, cryo, electron, microscopy, exposure, data has parent organization: University of California at San Francisco; California; USA NIGMS P01 GM111126;
NIH R01 GM031627
PMID:28250466 Restricted http://msg.ucsf.edu/em/software/motioncor2.html SCR_016499 MotionCor 2026-09-12 12:58:40 186
Pavian
 
Resource Report
Resource Website
10+ mentions
Pavian (RRID:SCR_016679) analysis service resource, data analysis service, production service resource, service resource, software resource, web application Software R package for interactive analysis of metagenomics classification results with a special focus on infectious disease diagnosis. Used for analyzing and visualization of metagenomics classification results from classifiers such as Kraken, Centrifuge and MetaPhlAn. Provides an alignment viewer for validation of matches to a particular genome. interactive, analysis, metagenomics, classification, result, infectious, disease, diagnosis, data, visualization, bio.tools is listed by: Debian
is listed by: bio.tools
is related to: Centrifuge Classifier
NHGRI R01 HG006677;
NIGMS R01 GM083873;
U. S. Army Research Office W911NF1410490
DOI:10.1101/084715 Free, Freely available biotools:pavian https://fbreitwieser.shinyapps.io/pavian/, https://bio.tools/pavian SCR_016679 2026-09-12 12:58:43 33

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