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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
RSEM
 
Resource Report
Resource Website
50+ mentions
RSEM (RRID:SCR_000262) software resource, data processing software, software application, data analysis software Software package for quantifying gene and isoform abundances from single end or paired end RNA Seq data. Accurate transcript quantification from RNA Seq data with or without reference genome. Used for accurate quantification of gene and isoform expression from RNA-Seq data. quantifying, gene, isoform, abundance, single, end, paired, RNA seq, data, transcript, reference, genome, bio.tools is listed by: OMICtools
is listed by: GitHub
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Wisconsin-Madison; Wisconsin; USA
PMID:21816040 Free, Available for download, Freely available OMICS_01966, OMICS_01287, biotools:rsem, SCR_013027 https://github.com/deweylab/RSEM, https://github.com/deweylab/RSEM/releases, https://bio.tools/rsem, https://sources.debian.org/src/rsem/ SCR_000262 RSEM, RNA-Seq by Expectation-Maximization, RSEM-v1.3.0 2026-08-05 10:43:08 94
DESeq
 
Resource Report
Resource Website
100+ mentions
DESeq (RRID:SCR_000154) DESeq software resource, data processing software, software application, data analysis software THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 30,2023. Software for differential gene expression analysis based on the negative binomial distribution. It estimates variance-mean dependence in count data from high-throughput sequencing assays and tests for differential expression. gene expression, binomial, differential, negative binomial distribution, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is hosted by: Bioconductor
PMID:20979621
DOI:10.1186/s13059-014-0550-8
THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01306, biotools:deseq https://bio.tools/deseq, https://sources.debian.org/src/r-bioc-deseq2/ SCR_000154 2026-08-05 10:43:07 473
POPBAM
 
Resource Report
Resource Website
POPBAM (RRID:SCR_000464) POPBAM software resource, data processing software, software application, data analysis software A tool to perform evolutionary or population-based analyses of next-generation sequencing data. POPBAM takes a BAM file as its input and can compute many widely used evolutionary genetics measures in sliding windows across a genome. next-generation sequencing, evolution, population, bam, genome, evolutionary genetics, c++, short read, sequence alignment, sliding window, command-line, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: SourceForge
has parent organization: University of Rochester; New York; USA
PMID:24027417 Free, Available for download, Freely available biotools:popbam, OMICS_01559 https://bio.tools/popbam http://popbam.sourceforge.net/ SCR_000464 2026-08-05 10:43:10 0
GASV
 
Resource Report
Resource Website
1+ mentions
GASV (RRID:SCR_000061) GASV software resource, data processing software, software application, data analysis software Software tool for identifying structural variants (SVs) from paired-end sequencing data.GASV distribution includes three components that are typically run in succession: the BAM file of unique paired-read mappings is processed; structural variants are identified by clustering discordant fragments; and a probabilistic algorithm improves the specificity of GASV predictions. paired-end sequencing data, structural variant, probabilistic algorithm, discordant fragment, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is related to: GASVPro
has parent organization: Brown University; Rhode Island; USA
Burroughs Wellcome Fund ;
Department of Defense Breast Cancer Research ;
ADVANCE Program at Brown University ;
NSF 0548311
PMID:19477992 Free, Available for download, Freely available biotools:gasv, OMICS_01352 http://compbio.cs.brown.edu/projects/gasv/, https://bio.tools/gasv SCR_000061 Geometric Analysis of Structural Variants 2026-08-05 10:43:06 4
BAIT
 
Resource Report
Resource Website
1+ mentions
BAIT (RRID:SCR_000511) BAIT data processing software, software application, data visualization software, data analysis software, software resource Software to create strand inheritance plots in data derived from the Strand-Seq sequencing protocol. The software is designed to be flexible with a range of species, and basic template folders can called to read in species-specific data. create strand inheritance plots, strand-seq, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: SourceForge
PMID:24028793 Free, Available for download, Freely available biotools:bait, OMICS_01531 https://bio.tools/bait SCR_000511 BAIT - Software to help analyse Strand-Seq data 2026-08-05 10:43:11 1
Skylign
 
Resource Report
Resource Website
10+ mentions
Skylign (RRID:SCR_001176) Skylign software resource, data analysis service, production service resource, service resource, analysis service resource A tool for creating logos representing both sequence alignments and profile hidden Markov models. The interactive logos enable scrolling, zooming, and inspection of underlying values. Skylign can avoid sampling bias in sequence alignments by down-weighting redundant sequences and by combining observed counts with informed priors. It also simplifies the representation of gap parameters, and can optionally scale letter heights based on alternate calculations of the conservation of a position. sequence alignment, profile, logo, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Janelia Research
PMID:24410852 Creative Commons Attribution License, v3 Unported biotools:skylign, OMICS_02182 https://bio.tools/skylign SCR_001176 Skylign - Interactive logos for alignments and profile HMMs 2026-08-05 10:43:19 13
sim4cc
 
Resource Report
Resource Website
sim4cc (RRID:SCR_001204) data processing software, image analysis software, software application, alignment software, software resource Software tool as cross species spliced alignment program.Heuristic sequence alignment tool for comparing cDNA sequence with genomic sequence containing homolog of gene in another species. Cross species spliced alignment, unix, sequence alignment, cdna sequence, genomic sequence, homolog, gene, splice, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Johns Hopkins University; Maryland; USA
NSF CLS20163A;
Sloan Research Fellowship ;
NLM R01 LM006845
PMID:19429899 Free, Available for download, Freely available biotools:sim4cc, OMICS_02145 https://bio.tools/sim4cc SCR_001204 2026-08-05 10:43:19 0
bsseq
 
Resource Report
Resource Website
1+ mentions
bsseq (RRID:SCR_001072) data processing software, software application, sequence analysis software, data analysis software, software resource R package with tools for analyzing and visualizing bisulfite sequencing data. bisulfite sequencing, analyze, r, sequence analysis software, data analysis software, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
Free, Available for download, Freely available OMICS_01847, biotools:bsseq https://bio.tools/bsseq SCR_001072 bsseq - Analyze manage and store bisulfite sequencing data 2026-08-05 10:43:18 8
SplitSeek
 
Resource Report
Resource Website
1+ mentions
SplitSeek (RRID:SCR_001012) data processing software, software application, sequence analysis software, data analysis software, software resource THIS RESOURCE IS NO LONGER IN SERVICE, documented September 20, 2016. A program for de novo prediction of splice junctions in RNA-seq data. bioinformatics alignment, sequence analysis software, de novo, prediction, rna seq, rna, splice junction, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
PMID:20236510 THIS RESOURCE IS NO LONGER IN SERVICE biotools:splitseek, OMICS_01253 https://bio.tools/splitseek http://www.uppmax.uu.se/software/splitseek SCR_001012 2026-08-05 10:43:17 1
AutoAssemblyD
 
Resource Report
Resource Website
AutoAssemblyD (RRID:SCR_001087) data processing software, software application, sequence analysis software, data analysis software, software resource Software which performs local and remote genome assembly by several assemblers based on an XML Template which can replace the large command lines required by most assemblers. genome, genome assembly, xml, sequence analysis software, local genome assembly, remote genome assembly, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: SourceForge
PMID:24143057 Free, Available for download, Freely available biotools:autoassemblyd, OMICS_00874 https://bio.tools/autoassemblyd SCR_001087 2026-08-05 10:43:18 0
UNAFold
 
Resource Report
Resource Website
100+ mentions
UNAFold (RRID:SCR_001360) software resource, data processing software, software application, data analysis software Software package for nucleic acid folding and hybridization prediction. It has capabilities to predict folding for single-stranded RNA or DNA through a combination of free energy minimization, partition function calculations and stochastic sampling. The program runs on Unix and Linux platforms as well as Mac OS X and Windows. software, nucleic acid, folding, hybridization, prediction, rna, dna, stochastic sampling, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: University at Albany; New York; USA
Free, Available for download, Freely available biotools:unafold, nif-0000-07753 http://mfold.rna.albany.edu/ SCR_001360 The UNAFold Web Server, UNAFold Web Server 2026-08-05 10:43:21 304
MetAMOS
 
Resource Report
Resource Website
10+ mentions
MetAMOS (RRID:SCR_011914) MetAMOS data processing software, software application, workflow software, software resource A modular and open source metagenomic assembly and analysis pipeline. microbiome, pipeline, microbiome, workflow software, metagenomic assembly, metagenomic assembly, bio.tools is listed by: OMICtools
is listed by: Human Microbiome Project
is listed by: bio.tools
is listed by: Debian
is hosted by: GitHub
Open source, Available for download OMICS_01426, biotools:metamos https://github.com/marbl/metAMOS, https://bio.tools/metamos SCR_011914 2026-08-05 10:45:37 14
KisSplice
 
Resource Report
Resource Website
10+ mentions
KisSplice (RRID:SCR_011893) KisSplice software resource, data processing software, software application, data analysis software Software tool that enables analysis of RNA-seq data with or without reference genome. Local transcriptome assembler for SNPs, indels and AS events. RNA-seq data analysis, with reference genome, without reference genome, local transcriptome assembler, SNPs, indels, AS events., bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
DOI:10.1186/1471-2105-13-S6-S5 Free, Available for download, Freely available biotools:KisSplice, OMICS_01321 https://bio.tools/KisSplice, https://sources.debian.org/src/kissplice/ SCR_011893 2026-08-05 10:45:37 20
ECHO
 
Resource Report
Resource Website
100+ mentions
ECHO (RRID:SCR_011851) ECHO data processing software, algorithm resource, software application, data analysis software, sequence analysis software, software resource Error correction algorithm designed for short-reads from next-generation sequencing platforms such as Illumina''s Genome Analyzer II. error correction, rnaseq, rna sequence, short-read, next-generation sequencing, ngs, illumina, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: SourceForge
PMID:21482625
DOI:10.1101/gr.111351.110
Free, Available for download biotools:echo, OMICS_01102 https://bio.tools/echo, https://sources.debian.org/src/uc-echo/ SCR_011851 ECHO: A reference-free short-read error correction algorithm 2026-08-05 10:45:37 310
CANGS
 
Resource Report
Resource Website
1+ mentions
CANGS (RRID:SCR_011837) CANGS software resource, data processing software, software application, data analysis software A user-friendly utility for processing and analyzing 454 GS-FLX data in biodiversity studies. windows, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
PMID:20180949 biotools:cangs, OMICS_01084 https://bio.tools/cangs SCR_011837 2026-08-05 10:45:37 1
JiffyNet
 
Resource Report
Resource Website
1+ mentions
JiffyNet (RRID:SCR_011954) software application, simulation software, software resource, data analysis service, production service resource, service resource, analysis service resource Web based instant protein network modeler for newly sequenced species. Web server designed to instantly construct genome scale protein networks using protein sequence data. Provides network visualization, analysis pages and solution for instant network modeling of newly sequenced species. protein network, protein, network, genome, sequence, pathway annotation, network visualization, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Yonsei University; Seoul; South Korea
National Research Foundation of Korea ;
Next-Generation BioGreen 21 Program
PMID:23685435 Free, Freely available OMICS_01548, biotools:jiffynet https://bio.tools/jiffynet SCR_011954 2026-08-05 10:45:38 1
sabre
 
Resource Report
Resource Website
100+ mentions
sabre (RRID:SCR_011843) sabre software resource, data processing software, software application, data analysis software Software tool to demultiplex barcoded reads into separate files. Works on both single-end and paired-end data in fastq format. Used in next generation sequencing to analyze a broad range of data. demultiplex, bardcode, separate, fastq, format, data, next, generation, sequencing, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
Free, Available for download, Freely available biotools:sabre, OMICS_01090 https://bio.tools/sabre SCR_011843 Systems Approach to Biomarker Research 2026-08-05 10:45:37 199
NGSmethDB
 
Resource Report
Resource Website
1+ mentions
NGSmethDB (RRID:SCR_012847) NGSmethDB data or information resource, data repository, database, storage service resource, service resource A dedicated database for the storage, browsing and data mining of whole-genome, single-base-pair resolution methylomes. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:20965971 OMICS_01844, biotools:ngsmethdb https://bio.tools/ngsmethdb SCR_012847 NGSmethDB - A database for NGS single-cytosine-resolution DNA methylation data 2026-08-05 10:45:53 9
TopHat
 
Resource Report
Resource Website
5000+ mentions
Rating or validation data
TopHat (RRID:SCR_013035) data processing software, software application, image analysis software, alignment software, data analysis software, sequence analysis software, software resource Software tool for fast and high throughput alignment of shotgun cDNA sequencing reads generated by transcriptomics technologies. Fast splice junction mapper for RNA-Seq reads. Aligns RNA-Seq reads to mammalian-sized genomes using ultra high-throughput short read aligner Bowtie, and then analyzes mapping results to identify splice junctions between exons.TopHat2 is accurate alignment of transcriptomes in presence of insertions, deletions and gene fusions. align, RNA-Seq, read, cDNA, sequencing, transcriptomics, fast, splice, junction, mapper, exon, analysis, bio.tools uses: Bowtie
is used by: CIRCexplorer
is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
is related to: HISAT2
has parent organization: University of Maryland; Maryland; USA
has parent organization: University of California at Berkeley; Berkeley; USA
has parent organization: Johns Hopkins University; Maryland; USA
has parent organization: University of Washington; Seattle; USA
works with: GeneScissors
NHGRI R01 HG006102;
NHGRI R01 HG006677
PMID:23618408
PMID:19289445
DOI:10.1093/bioinformatics/btp120
Free, Available for download, Freely available biotools:tophat, OMICS_01257 https://github.com/infphilo/tophat, https://bio.tools/tophat, https://sources.debian.org/src/tophat/ http://tophat.cbcb.umd.edu/ SCR_013035 tophat, TopHat1, Tophat2 2026-08-05 10:45:55 9575
MitoBreak
 
Resource Report
Resource Website
10+ mentions
MitoBreak (RRID:SCR_012949) MitoBreak data or information resource, data repository, database, storage service resource, service resource Database with curated datasets of mitochondrial DNA (mtDNA) rearrangements. Users may submit new mtDNA rearrangements. mitochondrial dna rearrangement, mitochondrial dna, deletion, duplication, linear, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:24170808 Free, The community can contribute to this resource biotools:mitobreak, OMICS_01640 https://bio.tools/mitobreak SCR_012949 2026-08-05 10:45:54 10

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