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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
GermOnline
 
Resource Report
Resource Website
10+ mentions
GermOnline (RRID:SCR_002807) GermOnline data or information resource, database Cross-species microarray expression database focusing on high-throughput expression data relevant for germline development, meiosis and gametogenesis as well as the mitotic cell cycle. The database contains a unique combination of information: 1) High-throughput expression data obtained with whole-genome high-density oligonucleotide microarrays (GeneChips). 2) Sample annotation (mouse over the sample name and click on it) using the Multiomics Information Management and Annotation System (MIMAS 3.0). 3) In vivo protein-DNA binding data and protein-protein interaction data (available for selected species). 4) Genome annotation information from Ensembl version 50. 5) Orthologs are identified using data from Ensembl and OMA and linked to each other via a section in the report pages. The portal provides access to the Saccharomyces Genomics Viewer (SGV) which facilitates online interpretation of complex data from experiments with high-density oligonucleotide tiling microarrays that cover the entire yeast genome. The database displays only expression data obtained with high-density oligonucleotide microarrays (GeneChips)., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 15,2026. fertility, development, germline, microarray, annotation, in vivo, protein-dna binding, protein-protein interaction, genome, ortholog, high-density oligonucleotide microarray, gene expression, genome annotation, gene orthology, genechip, tiling array, development, meiosis, gametogenesis, mitotic cell cycle, data set, data repository, bio.tools is listed by: 3DVC
is listed by: re3data.org
is listed by: bio.tools
is listed by: Debian
is related to: Ensembl
is related to: OMA Browser
has parent organization: National Institute of Health and Medical Research; Rennes; France
Swiss Institute of Bioinformatics ;
bioinformatics platform of Biogenouest ;
National Institute of Health and Medical Research; Rennes; France ;
University of Rennes 1; Rennes; France
PMID:21149299 THIS RESOURCE IS NO LONGER IN SERVICE biotools:germonline, nif-0000-02906, r3d100010248 https://bio.tools/germonline, https://doi.org/10.17616/R37K5Q SCR_002807 2026-09-19 12:56:37 17
HomoloGene
 
Resource Report
Resource Website
100+ mentions
HomoloGene (RRID:SCR_002924) HomoloGene data or information resource, database, service resource Automated system for constructing putative homology groups from complete gene sets of wide range of eukaryotic species. Databse that provides system for automatic detection of homologs, including paralogs and orthologs, among annotated genes of sequenced eukaryotic genomes. HomoloGene processing uses proteins from input organisms to compare and sequence homologs, mapping back to corresponding DNA sequences. Reports include homology and phenotype information drawn from Online Mendelian Inheritance in Man, Mouse Genome Informatics, Zebrafish Information Network, Saccharomyces Genome Database and FlyBase. homolog, paralog, ortholog, genome, gene, protein, protein alignment, phenotype, conserved domain, homology, amino acid sequence, cell, dna, gold standard is used by: NIF Data Federation
is used by: Nowomics
is used by: MitoMiner
is listed by: OMICtools
is listed by: re3data.org
is related to: OMIM
is related to: Mouse Genome Informatics (MGI)
is related to: Zebrafish Information Network (ZFIN)
is related to: SGD
is related to: FlyBase
is related to: ProbeMatchDB 2.0
is related to: Biomine
is related to: Consensus CDS
has parent organization: NCBI
PMID:23193264 Free, Freely availalbe nif-0000-02975, r3d100010781, OMICS_01544 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=homologene, https://doi.org/10.17616/R3889F SCR_002924 NCBI HomoloGene 2026-09-19 12:56:37 459
Zebrafish Information Network (ZFIN)
 
Resource Report
Resource Website
500+ mentions
Zebrafish Information Network (ZFIN) (RRID:SCR_002560) ZFIN data or information resource, database Model organism database that serves as central repository and web-based resource for zebrafish genetic, genomic, phenotypic and developmental data. Data represented are derived from three primary sources: curation of zebrafish publications, individual research laboratories and collaborations with bioinformatics organizations. Data formats include text, images and graphical representations.Serves as primary community database resource for laboratory use of zebrafish. Developed and supports integrated zebrafish genetic, genomic, developmental and physiological information and link this information extensively to corresponding data in other model organism and human databases. expression, gene, anatomy, development, disease, genomic, model, molecular, mutant, neuronal, organism, phenotype, physiological, synteny, zebrafish, gene expression, genome sequence, molecular neuroanatomy resource, genotype, anatomical structure, publication, genome, image collection, gold standard, bio.tools, FASEB list, RRID Community Authority uses: InterMOD
is used by: NIF Data Federation
is used by: Resource Identification Portal
is used by: Morpholino Database
is used by: Integrated Animals
is used by: NIH Heal Project
is recommended by: Resource Identification Portal
is recommended by: NIDDK Information Network (dkNET)
is recommended by: National Library of Medicine
is recommended by: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
is listed by: OMICtools
is listed by: InterMOD
is listed by: re3data.org
is listed by: bio.tools
is listed by: Debian
is related to: AmiGO
is related to: Phenoscape Knowledgebase
is related to: MONARCH Initiative
is related to: Bgee: dataBase for Gene Expression Evolution
is related to: NIH Data Sharing Repositories
is related to: HomoloGene
is related to: Zebrafish International Resource Center
is related to: Integrated Manually Extracted Annotation
is related to: Zebrafish Genome Project
has parent organization: University of Oregon; Oregon; USA
is parent organization of: ZFIN Antibody Database
is parent organization of: Zebrafish Anatomical Ontology
is parent organization of: ZFIN Protocol Wiki
is parent organization of: ZFIN Antibody Wiki
is organization facet of: Alliance of Genome Resources
NHGRI P41 HG002659;
NHGRI R01 HG004834
PMID:23074187
PMID:21036866
PMID:16381936
Free, Available for download, Freely available OMICS_01666, nif-0000-21427, biotools:zfin, r3d100010421, SCR_017504 http://zfin.org/ZFIN/misc_html/tips.html#newrecord, https://wiki.zfin.org/display/general/ZFIN+Data+Submissions, https://bio.tools/zfin, https://doi.org/10.17616/R3CK5Z SCR_002560 Zebrafish Database, The Zebrafish Model Organism Database, Zebra Model Organism Database, ZebraFish Information Network, ZFIN 2026-09-19 12:56:36 978
object-oriented Transcription Factors Database
 
Resource Report
Resource Website
1+ mentions
object-oriented Transcription Factors Database (RRID:SCR_002435) data or information resource, database ooTFD (object-oriented Transcription Factors Database) is a successor to TFD, the original Transcription Factors Database. This database is aimed at capturing information regarding the polypeptide interactions which comprise and define the properties of transcription factors. ooTFD contains information about transcription factor binding sites, as well as composite relationships within transcription factors, which frequently occur as multisubunit proteins that form a complex interface to cellular processes outside the transcription machinery through protein-protein interactions. ooTFD contains information represented in TFD but also allows the representation of containment, composite, and interaction relationships between transcription factor polypeptides. It is designed to represent information about all transcription factors, both eukaryotic and prokaryotic, basal as well as regulatory factors, and multiprotein complexes as well as monomers. eukaryotic, expression, factor, gene, basal, binding site, biochemical, biology, cellular, complex, genome, genomic, information, interaction, molecule, monomer, multisubunit, nucleotide sequences, transcriptional regulator sites, transcription factors, object, polypeptide, process, prokaryotic, property, protein, protein-protein interaction, regulatory, sequence, transcription has parent organization: IFTI-Mirage PMID:10592257
PMID:9847215
PMID:9399874
Free, Freely available nif-0000-21303 SCR_002435 ooTFD 2026-09-19 12:56:36 2
ABS: A Database of Annotated Regulatory Binding Sites From Orthologous Promoters
 
Resource Report
Resource Website
1+ mentions
ABS: A Database of Annotated Regulatory Binding Sites From Orthologous Promoters (RRID:SCR_002276) ABS data or information resource, database Public database of known binding sites identified in promoters of orthologous vertebrate genes that have been manually curated from bibliography. We have annotated 650 experimental binding sites from 68 transcription factors and 100 orthologous target genes in human, mouse, rat or chicken genome sequences. Computational predictions and promoter alignment information are also provided for each entry. For each gene, TFBSs conserved in orthologous sequences from at least two different species must be available. Promoter sequences as well as the original GenBank or RefSeq entries are additionally supplied in case of future identification conflicts. The final TSS annotation has been refined using the database dbTSS. Up to this release, 500 bps upstream the annotated transcription start site (TSS) according to REFSEQ annotations have been always extracted to form the collection of promoter sequences from human, mouse, rat and chicken. For each regulatory site, the position, the motif and the sequence in which the site is present are available in a simple format. Cross-references to EntrezGene, PubMed and RefSeq are also provided for each annotation. Apart from the experimental promoter annotations, predictions by popular collections of weight matrices are also provided for each promoter sequence. In addition, global and local alignments and graphical dotplots are also available. gene, alignment, annotation, binding, computational, genome, nucleotide, ortholog, prediction, promoter, sequence, target, transcription, transcriptional factor, binding site, promoter sequence, protein motif, benchmark, transcription factor binding site, bio.tools is listed by: bio.tools
is listed by: Debian
is related to: IntegromeDB
has parent organization: Center for Genomic Regulation; Barcelona; Spain
European Union FP6 contract LSHG-CT-2003-503265 PMID:16381947 Acknowledgement requested, GNU General Public License, v2 biotools:alggen, nif-0000-21006 https://bio.tools/alggen SCR_002276 A database of Annotated regulatory Binding Sites from orthologous promoters 2026-09-19 12:56:34 3
EcoCyc
 
Resource Report
Resource Website
500+ mentions
EcoCyc (RRID:SCR_002433) EcoCyc, EcoCyc REF data or information resource, database Database for the bacterium Escherichia coli K-12 MG1655, the EcoCyc project performs literature-based curation of the entire genome, and of transcriptional regulation, transporters, and metabolic pathways. The long-term goal of the project is to describe the molecular catalog of the E. coli cell, as well as the functions of each of its molecular parts, to facilitate a system-level understanding of E. coli. EcoCyc is an electronic reference source for E. coli biologists, and for biologists who work with related microorganisms. genome, metabolic pathway, transcription, transporters, escherichia coli, transcriptional regulation, metabolism, pathway, FASEB list uses: Pathway Tools
is used by: NIF Data Federation
is listed by: OMICtools
is listed by: BioCyc
is related to: MultiFun
is related to: BioCyc
is related to: BioCyc
is related to: AmiGO
is related to: NCBI BioSystems Database
is related to: Pathway Tools
has parent organization: Stanford Research Institute International
NCRR ;
NIGMS GM077678;
NIGMS GM71962
PMID:23143106
PMID:21097882
Free, Freely available OMICS_01645, nif-0000-02783, r3d100011277 https://doi.org/10.17616/R34K99 SCR_002433 EcoCyc REF 2026-09-19 12:56:36 511
CampyDB: Campylobacter Database
 
Resource Report
Resource Website
1+ mentions
CampyDB: Campylobacter Database (RRID:SCR_002299) data or information resource, database CampyDB is a database for comparative genome analysis of For Campylobacter, Helicobacter and Wolinella. The database contains information on: -Campylobacter coli RM2228 -Campylobacter concisus 13826 -Campylobacter curvus 525.92 -Campylobacter fetus subsp. fetus 82-40 -Campylobacter hominis ATCC BAA-381 -Campylobacter jejuni RM1221 -Campylobacter jejuni subsp. doylei 269.97 -Campylobacter jejuni subsp. jejuni 260.94 -Campylobacter jejuni subsp. jejuni 81-176 -Campylobacter jejuni subsp. jejuni 81-176 -Campylobacter jejuni subsp. jejuni 84-25 -Campylobacter jejuni subsp. jejuni CF93-6 -Campylobacter jejuni subsp. jejuni CG8486 -Campylobacter jejuni subsp. jejuni HB93-13 -Campylobacter jejuni subsp. jejuni NCTC 11168 -Campylobacter lari RM2100 -Campylobacter upsaliensis RM3195 -Helicobacter acinonychis str. Sheeba -Helicobacter hepaticus ATCC 51449 -Helicobacter pylori 26695 -Helicobacter pylori HPAG1 -Helicobacter pylori J99 -Thiomicrospira denitrificans ATCC 33889 -Wolinella succinogenes DSM 1740 Sponsors: The project was originally conceived in 2002 by Roy Chaudhuri and Mark Pallen at the University of Birmingham, as part of a BBSRC funded Exploiting Genomics (ExGen) consortium. CampyDB is developed and maintained by Nick Loman and Lori Snyder working in the Pallen Research Group at University of Birmingham and is supported by a 5 year BBSRC grant until Feburary 2012. campylobacter, comparative, genome, helicobacter, prokaryote databases, wolinella nif-0000-21075 SCR_002299 CampyDB 2026-09-19 12:56:35 4
Entrez Gene
 
Resource Report
Resource Website
1000+ mentions
Entrez Gene (RRID:SCR_002473) NCBI_Gene, NCBI Genen NCBI Entrez data or information resource, database Database for genomes that have been completely sequenced, have active research community to contribute gene-specific information, or that are scheduled for intense sequence analysis. Includes nomenclature, map location, gene products and their attributes, markers, phenotypes, and links to citations, sequences, variation details, maps, expression, homologs, protein domains and external databases. All entries follow NCBI's format for data collections. Content of Entrez Gene represents result of curation and automated integration of data from NCBI's Reference Sequence project (RefSeq), from collaborating model organism databases, and from many other databases available from NCBI. Records are assigned unique, stable and tracked integers as identifiers. Content is updated as new information becomes available. gene, gene expression, gene location, gene map, gene prediction, genome, genome sequence analysis, phenotype, nomenclature, gene mapping, protein, genetic code, function, annotation, gold standard, bio.tools is used by: Animal QTLdb
is used by: NIF Data Federation
is used by: LIPID MAPS Proteome Database
is used by: DisGeNET
is used by: Nowomics
is used by: Cytokine Registry
is used by: Pathway Analysis Tool for Integration and Knowledge Acquisition
is used by: Vesiclepedia
is listed by: OMICtools
is listed by: re3data.org
is listed by: bio.tools
is listed by: Debian
is related to: Rat Gene Symbol Tracker
is related to: Gene Reference into Function
is related to: Integrated Molecular Interaction Database
is related to: Biomine
is related to: SEGS
is related to: STOP
is related to: Coremine Medical
is related to: Consensus CDS
is related to: WebGestalt: WEB-based GEne SeT AnaLysis Toolkit
is related to: Array Information Library Universal Navigator
is related to: biomaRt
has parent organization: NCBI
works with: Open Regulatory Annotation Database
PMID:17148475
PMID:21115458
Free, Freely available nif-0000-02801, biotools:entrez_gene, OMICS_01651, r3d100010650 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene, http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene, https://bio.tools/entrez_gene, https://doi.org/10.17616/R3603S SCR_002473 NCBI Gene, Gene - Gene mapped phenotypes, Gene - Gene and mapped phenotypes, Gene Database, GeneID 2026-09-19 12:56:36 2912
Fungal Databases
 
Resource Report
Resource Website
100+ mentions
Fungal Databases (RRID:SCR_002350) data or information resource, database This website contains a list of five fungal genome databases from The J. Craig Venter Institute. Aspergillus genomes: -Aspergillus fumigatus (strain-Af 293) -Aspergillus clavatus -Neosartorya fischeri Other Fungal Genomes: -Cryptococcus neoformans (strain-JEC21) -Coccidioides posadasii fumigatus, fungal, fungal genome databases, aspergillus, clavatus, coccidioides posadasii, cryptococcus neoformans, genome, neosartorya fischeri, FASEB list has parent organization: J. Craig Venter Institute nif-0000-21158 SCR_002350 Fungal Databases 2026-09-19 12:56:35 281
DBTSS: Database of Transcriptional Start Sites
 
Resource Report
Resource Website
100+ mentions
DBTSS: Database of Transcriptional Start Sites (RRID:SCR_002354) DBTSS data or information resource, database Database of transcriptional start sites (TSSs) representing exact positions in the genome based on a unique experimentally validated TSS sequencing method, TSS Seq. A major part of human adult and embryonic tissues are covered. DBTSS contains 491 million TSS tag sequences collected from a total of 20 tissues and 7 cell cultures. Also integrated is generated RNA-seq data of subcellular- fractionated RNAs and ChIP Seq data of histone modifications, RNA polymerase II and several transcriptional regulatory factors in cultured cell lines. Also included is external epigenomic data, such as chromatin map of the ENCODE project. They associated those TSS information with public and original SNV data, in order to identify single nucleotide variations (SNVs) in the regulatory regions. cdna, cdna library, transcriptional start site, transcriptome, transcriptome analysis, tss-seq, genome, adult human, embryonic, cell, rna-seq, subcellular, rna, chip seq data, histone modification, rna polymerase ii, transcriptional regulatory factor, cell line, single nucleotide variation, regulatory region, genetic valuation, transcriptional regulation, bio.tools, FASEB list is used by: Transcriptional Regulatory Element Database
is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Tokyo; Tokyo; Japan
Japan Society for the Promotion of Science ;
Japanese Ministry of Education Culture Sports Science and Technology MEXT
PMID:22086958
PMID:19910371
PMID:17942421
PMID:16381981
PMID:14681363
PMID:11752328
nif-0000-02738, biotools:dbtss, OMICS_01860 https://bio.tools/dbtss SCR_002354 DBTSS: Database of Transcriptional Start Sites, DataBase of Transcriptional Start Sites 2026-09-19 12:56:35 127
GeneSeer
 
Resource Report
Resource Website
GeneSeer (RRID:SCR_002626) GeneSeer data or information resource, database THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 14,2026. Database to access gene information through common names and allows identification of homologs and paralogs for a given gene. This publicly available tool leverages public sequence data, gene metadata information, and other publicly available data to calculate and display orthologous and paralogous gene relationships for all genes from several species, including yeasts, insects, worms, vertebrates, mammals, and primates such as humans. gene, homolog, paralog, genome, search engine, ortholog PMID:16176584 THIS RESOURCE IS NO LONGER IN SERVICE nlx_156048 http://katahdin.mssm.edu/geneseer/scripts/main.pl http://geneseer.cshl.org/ SCR_002626 2026-09-19 12:56:36 0
Silkworm Genome Database
 
Resource Report
Resource Website
1+ mentions
Silkworm Genome Database (RRID:SCR_008242) data or information resource, database Silkbase''s objective is to build a foundation for the complete genome analysis of Bombyx mori. anopheles gambiae, bombyx mori, drosophila, genome, moth, samia cynthia invertebrate databases has parent organization: University of Tokyo; Tokyo; Japan nif-0000-21370 SCR_008242 Silkworm Genome Database 2026-09-19 12:57:16 3
Cytokine Family Database
 
Resource Report
Resource Website
1+ mentions
Cytokine Family Database (RRID:SCR_008134) data or information resource, database THIS RESOURCE IS NO LONGER IN SERVICE, documented on August 26, 2016. A collection of cDNA, gene and protein records of cytokines deposited in public databases provides various information about the cytokine members of vertebrates in other databases including NCBI GenBank, Swiss-Prot, UniGene, TIGR (The Institute for Genomic Research) Gene Indices, Ensembl, Entrez Gene, Mouse Genome Informatics (MGI) and Rat Genome Database (RGD). It also provides orthologous relationship of cytokine members and includes novel members identified in the databases. family, fish, gene, amphibian, bird, cdna, chemokine, cow, cytokine, genome, human, mammalian, mouse, oncogene, phylogenetic, protein, rat, receptor, reptile, virus is listed by: 3DVC
has parent organization: Kumamoto University; Kumamoto; Japan
Japan Society for the Promotion of Science THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-20948 http://cytokine.medic.kumamoto-u.ac.jp/ SCR_008134 dbCFC 2026-09-19 12:57:15 1
Animal Genome Database
 
Resource Report
Resource Website
1+ mentions
Animal Genome Database (RRID:SCR_008165) data or information resource, database Database of comparative gene mapping between species to assist the mapping of the genes related to phenotypic traits in livestock. The linkage maps, cytogenetic maps, polymerase chain reaction primers of pig, cattle, mouse and human, and their references have been included in the database, and the correspondence among species have been stipulated in the database. AGP is an animal genome database developed on a Unix workstation and maintained by a relational database management system. It is a joint project of National Institute of Agrobiological Sciences (NIAS) and Institute of the Society for Techno-innovation of Agriculture, Forestry and Fisheries (STAFF-Institute), under cooperation with other related research institutes. AGP also contains the Pig Expression Data Explorer (PEDE), a database of porcine EST collections derived from full-length cDNA libraries and full-length sequences of the cDNA clones picked from the EST collection. The EST sequences have been clustered and assembled, and their similarity to sequences in RefSeq, and UniGene determined. The PEDE database system was constructed to store sequences and similarity data of swine full-length cDNA libraries and to make them available to users. It provides interfaces for keyword and ID searches of BLAST results and enables users to obtain sequence data and names of clones of interest. Putative SNPs in EST assemblies have been classified according to breed specificity and their effect on coding amino acids, and the assemblies are equipped with an SNP search interface. The database contains porcine nucleotide sequences and cDNA clones that are ready for analyses such as expression in mammalian cells, because of their high likelihood of containing full-length CDS. PEDE will be useful for researchers who want to explore genes that may be responsible for traits such as disease susceptibility. The database also offers information regarding major and minor porcine-specific antigens, which might be investigated in regard to the use of pigs as models in various medical research applications. est, expression, gene, amino acid, animal, antigen, breed, cattle, cdna, cell, chain, clone, coding, cytogenetic, genome, human, linkage, livestock, mammalian, map, mouse, nucleotide, organism, phenotypic, pig, polymerase, porcine, primer, reaction, sequence, snp, specie, swine, trait has parent organization: National Institute of Agrobiological Sciences; Ibaraki; Japan nif-0000-21029 SCR_008165 AGP 2026-09-19 12:57:15 1
Phylogenetic Clusters of Orthologous Groups Ranking
 
Resource Report
Resource Website
1+ mentions
Phylogenetic Clusters of Orthologous Groups Ranking (RRID:SCR_008223) data or information resource, database THIS RESOURCE IS NO LONGER IN SERVICE, documented on August 20,2019.The COG-database has become a powerful tool in the field of comparative genomics. The construction of this data-base is based on sequence homologies of proteins from different completely sequenced genomes. Highly homologous proteins are assigned to clusters of orthologous groups. The updated collection of orthologous protein sets for prokaryotes and eukaryotes is expected to be a useful platform for functional annotation of newly sequenced genomes, including those of complex eukaryotes, and genome-wide evolutionary studies. The availability of multiple, essentially complete genome sequences of prokaryotes and eukaryotes spurred both the demand and the opportunity for the construction of an evolutionary classification of genes from these genomes. Such a classification system based on orthologous relationships between genes appears to be a natural framework for comparative genomics and should facilitate both functional annotation of genomes and large-scale evolutionary studies. Here is a major update of the previously developed system for delineation of Clusters of Orthologous Groups of proteins (COGs) from the sequenced genomes of prokaryotes and unicellular eukaryotes and the construction of clusters of predicted orthologs for 7 eukaryotic genomes, which we named KOGs after eukaryotic orthologous groups. The COG collection currently consists of 138,458 proteins, which form 4873 COGs and comprise 75% of the 185,505 (predicted) proteins encoded in 66 genomes of unicellular organisms. The eukaryotic orthologous groups (KOGs) include proteins from 7 eukaryotic genomes: three animals (the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster and Homo sapiens), one plant, Arabidopsis thaliana, two fungi (Saccharomyces cerevisiae and Schizosaccharomyces pombe), and the intracellular microsporidian parasite Encephalitozoon cuniculi. The current KOG set consists of 4852 clusters of orthologs, which include 59,838 proteins, or approximately 54% of the analyzed eukaryotic 110,655 gene products. Compared to the coverage of the prokaryotic genomes with COGs, a considerably smaller fraction of eukaryotic genes could be included into the KOGs; addition of new eukaryotic genomes is expected to result in substantial increase in the coverage of eukaryotic genomes with KOGs. Examination of the phyletic patterns of KOGs reveals a conserved core represented in all analyzed species and consisting of approximately 20% of the KOG set. This conserved portion of the KOG set is much greater than the ubiquitous portion of the COG set (approximately 1% of the COGs). In part, this difference is probably due to the small number of included eukaryotic genomes, but it could also reflect the relative compactness of eukaryotes as a clade and the greater evolutionary stability of eukaryotic genomes. elegans, encephalitozoon, eukaryote, evolutionary, fly, fruit, fungus, gene, general genomics databases, animal, arabidopsis, caenorhabditis, cerevisiae, classification, comparative, cuniculi, drosophila, genome, genomic, homo, homology, intracellular, melanogaster, microsporidian, nematode, organism, ortholog, orthologous, parasite, pattern, phyletic, phylogenetic, plant, pombe, prokaryote, protein, saccharomyces, sapiens, schizosaccharomyces, sequence, thaliana, tool, unicellular has parent organization: National Institutes of Health THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-21313 SCR_008223 PCOGR 2026-09-19 12:57:16 3
Comparative Vertebrate Sequencing
 
Resource Report
Resource Website
Comparative Vertebrate Sequencing (RRID:SCR_008213) data or information resource, database Generates data for use in developing and refining computational tools for comparing genomic sequence from multiple species. The NISC Comparative Sequencing Program's goal is to establish a data resource consisting of sequences for the same set of targeted genomic regions derived from multiple animal species. The broader program includes plans for a diverse set of analytical studies using the generated sequence and the publication of a series of papers describing the results of those analysis in peer-reviewed journals in a timely fashion. Experimentally, this project involves the shotgun sequencing of mapped BAC clones. For each BAC, an assembly is first performed when a sufficient number of sequence reads have been generated to provide full shotgun coverage of the clone. At that time, the assembled sequence is submitted to the HTGS division of GenBank. Subsequent refinements of the sequence, including the generation of higher-accuracy finished sequence, results in the updating of the sequence record in GenBank. By immediately submitting our BAC-derived sequences to GenBank, it makes their data available as a public service to allow colleagues to speed up their research, consistent with the now well-established routine of sequencing centers participating in the Human Genome Project. However, at the same time, it has made considerable investment in acquiring these mapping and sequence data, including sizable efforts of graduate students, postdoctoral fellows, and other trainees. Furthermore, in most cases, large data sets involving multiple BAC sequences from multiple species must first be generated, often taking many months to accumulate, before the planned analysis can be performed and the resulting papers written and submitted for publication. accuracy, animal, bac, clone, comparative, computational, genome, genomic, human, map, mapping, model organisms and comparative genomics databases, sequence, specie, tool has parent organization: National Institutes of Health nif-0000-21291 SCR_008213 Comparative Vertebrate Sequencing 2026-09-19 12:57:16 0
Peroxisome Database
 
Resource Report
Resource Website
10+ mentions
Peroxisome Database (RRID:SCR_008352) data or information resource, database The aim of the PEROXISOME database (PeroxisomeDB) is to gather, organize and integrate curated information on peroxisomal genes, their encoded proteins, their molecular function and metabolic pathway they belong to, and their related disorders. PeroxisomeDB contains the complete peroxisomal proteome of Homo sapiens (encoded by 85 genes) and Saccharomyces cerevisiae (encoded by 61 genes). Now, we have included 34 new organism genomes with the acquisition of 2426 new peroxisomal homolog proteins. PeroxisomeDB 2.0 integrates the peroxisomal metabolome of whole microbody family by the new incorporation of the glycosome proteomes of trypanosomatids and the glyoxysome proteome of Arabidopsis thaliana. The site also provides a Peroxisome Metabolome of peroxisomal genes and proteins, their molecular interactions and metabolic pathways, tools for comparative genomics, predictive tools. Sponsors: Preoxisome Database is funded by Institut de Gntique et deBiologie Molculaire et Cellulaire. family, function, gene, arabidopsis thaliana, disorder, genome, genomic, glycosome, glyoxysome, homolog, homo sapiens, interaction, metabolic, metabolome, microbody, molecular, organism, pathway, peroxisome, protein, proteome, saccharomyces cerevisiae, trypanosomatid nif-0000-25216 SCR_008352 Preoxisomedb 2026-09-19 12:57:17 31
Structure modeling of 907 G protein coupled receptors in the human genome
 
Resource Report
Resource Website
1+ mentions
Structure modeling of 907 G protein coupled receptors in the human genome (RRID:SCR_008351) data or information resource, database THIS RESOURCE IS NO LONGER IN SERVICE, documented on August 19,2019.Database of tertiary structural modeling results of threading assembly refinement (TASSER) method for all 907 G protein-coupled receptors (GPCRs) in human genome. All sequences were collected from GPCR database http://www.gpcr.org/7tm/ and http://www.expasy.org/cgi-bin/lists?7tmrlist.txt. Unlike traditional homology modeling approaches, TASSER modeling does not require solved homologous template structures; moreover, it often refines the structures closer to native. G protein-coupled receptors (GPCRs), encoded by about 5% of human genes, comprise the largest family of integral membrane proteins and act as cell surface receptors responsible for the transduction of endogenous signal into a cellular response. Although tertiary structural information is crucial for function annotation and drug design, there are few experimentally determined GPCR structures. To address this issue, we employ the recently developed threading assembly refinement (TASSER) method to generate structure predictions for all 907 putative GPCRs in the human genome. Unlike traditional homology modeling approaches, TASSER modeling does not require solved homologous template structures; moreover, it often refines the structures closer to native. These features are essential for the comprehensive modeling of all human GPCRs when close homologous templates are absent. Based on a benchmarked confidence score, approximately 820 predicted models should have the correct folds. The majority of GPCR models share the characteristic seven-transmembrane helix topology, but 45 ORFs are predicted to have different structures. This is due to GPCR fragments that are predominantly from extracellular or intracellular domains as well as database annotation errors. Our preliminary validation includes the automated modeling of bovine rhodopsin, the only solved GPCR in the Protein Data Bank. With homologous templates excluded, the final model built by TASSER has a global C(alpha) root-mean-squared deviation from native of 4.6 angstroms, with a root-mean-squared deviation in the transmembrane helix region of 2.1 angstroms. Models of several representative GPCRs are compared with mutagenesis and affinity labeling data, and consistent agreement is demonstrated. Structure clustering of the predicted models shows that GPCRs with similar structures tend to belong to a similar functional class even when their sequences are diverse. These results demonstrate the usefulness and robustness of the in silico models for GPCR functional analysis. Sponsors: GPCR is funded by the University at Buffalo, Buffalo, New York. endogenous, extracellular, family, functional, gene, cellular, couple, genome, gpcr, g protein, helix, homology, human, membrane, model, modeling, orf, protein, receptor, response, signal, structural, structural model, structure, template, tertiary, topology, transduction, transmembrane has parent organization: Georgia Institute of Technology; Georgia; USA THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-25215 SCR_008351 GPCR 2026-09-19 12:57:17 3
Metagenomics Program at JGI
 
Resource Report
Resource Website
1+ mentions
Metagenomics Program at JGI (RRID:SCR_008804) JGI Metagenomics Program data or information resource, database Portal providing access to metagenomics projects, data and tools supported by the DOE Joint Genome Institute (JGI). A primary motivation for metagenomics is that most microbes found in nature exist in complex, interdependent communities and cannot readily be grown in isolation in the laboratory. One can, however, isolate DNA or RNA from the community as a whole, and studies of such communities have revealed a diversity of microbes far beyond those found in culture collections. It is suspected that these uncultivated organisms must harbor considerable as-yet undiscovered genomic, functional, and metabolic features and capabilities. Thus to fully explore microbial genomics, it is imperative that we access the genomes of these elusive players. genome, comparative analysis, metagenome, microbial, environment, terrestrial, aquatic, marine, freshwater, engineered, thermal spring, soil, host-associated, sequence, gene is listed by: 3DVC
has parent organization: DOE Joint Genome Institute
DOE nlx_144368 SCR_008804 2026-09-19 12:57:19 1
Ensembl Fungi
 
Resource Report
Resource Website
100+ mentions
Ensembl Fungi (RRID:SCR_008681) data or information resource, database The Ensembl Genomes project produces genome databases for important species from across the taxonomic range, using the Ensembl software system. Five sites are now available, one of which is Ensembl Fungi, which houses fungal species. Sponsors: EnsembFungi is a project run by EMBL - EBI to maintain annotation on selected genomes, based on the software developed in the Ensembl project developed jointly by the EBI and the Wellcome Trust Sanger Institute. fungus, database, genome, software, specie, taxonomic, FASEB list has parent organization: Ensembl nif-0000-33718, r3d100011196 https://doi.org/10.17616/R3RK74, https://doi.org/10.17616/R3RK74 SCR_008681 EnsemblFungi 2026-09-19 12:57:19 261

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