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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
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IDbases Resource Report Resource Website 10+ mentions |
IDbases (RRID:SCR_002378) | data repository, data or information resource, database, storage service resource, service resource | IDbases are locus-specific databases for immunodeficiency-causing mutations. Our aim is to establish database for every immunodeficiency or provide links to those maintained elsewhere. IDbases contain in addition to gene mutation, also information about clinical presentation. Information has been collected from literature as well as received directly from researchers. It would be most glad if those analyzing mutations would send their information by using the interactive web submission available in each database. A number of articles have been published related to IDbases. IDbases are curated and distributed with proprietary MUTbase software suite. | gene, clinical, database, immunodeficiency, immunological database, locus, mutation, presentation, specific | has parent organization: University of Tampere; Tampere; Finland | PMID:17004234 | nif-0000-21214 | SCR_002378 | IDbases | 2026-08-03 09:31:48 | 16 | ||||||||
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PharmGKB Resource Report Resource Website 1000+ mentions |
PharmGKB (RRID:SCR_002689) | PharmGKB | data repository, web service, data or information resource, database, storage service resource, data access protocol, service resource, software resource, data set | Database and central repository for genetic, genomic, molecular and cellular phenotype data and clinical information about people who have participated in pharmacogenomics research studies. The data includes, but is not limited to, clinical and basic pharmacokinetic and pharmacogenomic research in the cardiovascular, pulmonary, cancer, pathways, metabolic and transporter domains. PharmGKB welcomes submissions of primary data from all research into genes and genetic variation and their effects on drug and disease phenotypes. PharmGKB collects, encodes, and disseminates knowledge about the impact of human genetic variations on drug response. They curate primary genotype and phenotype data, annotate gene variants and gene-drug-disease relationships via literature review, and summarize important PGx genes and drug pathways. PharmGKB is part of the NIH Pharmacogenomics Research Network (PGRN), a nationwide collaborative research consortium. Its aim is to aid researchers in understanding how genetic variation among individuals contributes to differences in reactions to drugs. A selected subset of data from PharmGKB is accessible via a SOAP interface. Downloaded data is available for individual research purposes only. Drugs with pharmacogenomic information in the context of FDA-approved drug labels are cataloged and drugs with mounting pharmacogenomic evidence are listed. | pharmacogenomics, microarray, pathway, phenotype, snp array, genotype, clinical, genetic variation, drug, gene, genetic variation, disease, cardiovascular, pulmonary, cancer, metabolic, transporter, drug response, small molecule, research, drug response, FASEB list |
is used by: NIF Data Federation is listed by: OMICtools is related to: WikiPathways is related to: ConsensusPathDB is related to: Integrated Molecular Interaction Database is related to: MalaCards is related to: phenomeNET has parent organization: Stanford University; Stanford; California is parent organization of: PharmGKB Ontology |
NIGMS R24 GM61374 | PMID:11908751 | Free, Freely available | nif-0000-00414, OMICS_01586, r3d100012325 | https://doi.org/10.17616/R31H1N | SCR_002689 | Pharmacogenomics Knowledge Base | 2026-08-03 09:31:57 | 1152 | ||||
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Parkinson’s Disease Biomarkers Program Data Management Resource (PDBP DMR) Resource Report Resource Website 10+ mentions |
Parkinson’s Disease Biomarkers Program Data Management Resource (PDBP DMR) (RRID:SCR_002517) | PDBP | service resource, biospecimen repository, material storage repository, storage service resource | Common data management resource and web portal to promote discovery of Parkinson's Disease diagnostic and progression biomarker candidates for early detection and measurement of disease progression. PDBP will serve as multi-faceted platform for integrating existing biomarker efforts, standardizing data collection and management across these efforts, accelerating discovery of new biomarkers, and fostering and expanding collaborative opportunities for all stakeholders. | parkinson's, clinical neuroinformatics, magnetic resonance, diagnostic, progression, biomarker, clinical |
is recommended by: National Library of Medicine is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC) is related to: NINDS Repository is related to: MIPAV: Medical Image Processing and Visualization has parent organization: National Institute of Neurological Disorders and Stroke |
Parkinson's disease | nlm ; NINDS |
PMID:25976927 | Restricted | nlx_155919 | http://www.nitrc.org/projects/pdbp | http://pdbp.ninds.nih.gov/index.jsp | SCR_002517 | Parkinson's Disease Biomarkers Program, PDBP: Parkinsons Disease Biomarkers Program, Parkinson’s Disease Biomarkers Program Data Management Resource, PDBP DMR | 2026-08-03 09:31:52 | 24 | ||
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NCBI database of Genotypes and Phenotypes (dbGap) Resource Report Resource Website 500+ mentions |
NCBI database of Genotypes and Phenotypes (dbGap) (RRID:SCR_002709) | dbGaP | data repository, data or information resource, database, storage service resource, service resource | Database developed to archive and distribute clinical data and results from studies that have investigated interaction of genotype and phenotype in humans. Database to archive and distribute results of studies including genome-wide association studies, medical sequencing, molecular diagnostic assays, and association between genotype and non-clinical traits. | clinical, trial, genotype, interaction, homology, cell, morphology, interaction, phenotype, molecular diagnosis, genetic recombination, gold standard, bio.tools |
is used by: International Genomics of Alzheimers Project is used by: NIDDK Inflammatory Bowel Disease Genetics Consortium is used by: NIH Heal Project is used by: Genomic Data Commons Data Portal (GDC Data Portal) is recommended by: National Library of Medicine is recommended by: NIDDK Information Network (dkNET) is recommended by: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases is listed by: OMICtools is listed by: re3data.org is listed by: NIDDK Information Network (dkNET) is listed by: bio.tools is listed by: Debian is related to: NIDDK Central Repository is related to: eMERGE Network: electronic Medical Records and Genomics is related to: Framingham Heart Study is related to: PhenoExplorer is related to: Chronic Renal Insufficiency Cohort Study is related to: DbGaP Cleaner is related to: Psychiatric Genomics Consortium is related to: ISCA Consortium is related to: Allen Institute for Brain Science has parent organization: NCBI is parent organization of: Resource for Genetic Epidemiology Research on Adult Health and Aging |
NLM | PMID:24297256 PMID:17898773 |
Restricted | nif-0000-23342, OMICS_00263, biotools:dbgap, r3d100010788 | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gap, https://bio.tools/dbgap, https://doi.org/10.17616/R3GS4K | SCR_002709 | database of Genotypes and Phenotypes (dbGaP), dbGaP, NCBI, Database of Genotypes and Phenotypes | 2026-08-03 09:31:48 | 683 | ||||
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Dana Foundation Resource Report Resource Website 10+ mentions |
Dana Foundation (RRID:SCR_002789) | book, training service resource, service resource, journal article, narrative resource, funding resource, blog, outreach program, podcast, data or information resource, training resource, training material | A private philanthropy with principal interests in brain science, immunology, and education. The portal provides general information about the brain and current brain research, links to validated sites related brain disorders, education resources and lesson plans, and support for the training of in-school arts specialists. The Dana Foundation science and health grants support brain research in neuroscience and immunology and their interrelationship in human health and disease. The grant sections include brain and immuno-imaging, clinical neuroscience research, human immunology and neuroimmunology. The Foundation also occasionally sponsors workshops and forums for working scientists, as well as offering funding for selected young researchers to continue their education or to attend seminars and workshops elsewhere. | education, foundation, funding resource, human brain, clinical, development, disease, disorder, grant, neruroimmunology, neuroethics, neuroscience, philanthropy, podcast, research | is parent organization of: Dana Foundation: BrainWeb | Free | nif-0000-24463 | SCR_002789 | The Dana Foundation | 2026-08-03 09:32:09 | 21 | ||||||||
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Neurogenetics and Behavior Center Resource Report Resource Website |
Neurogenetics and Behavior Center (RRID:SCR_002851) | portal, production service resource, service resource, topical portal, behavioral analysis service, analysis service resource, data or information resource | This center provides routine behavioral/cognitive testing of mice with phenotypes that are expressed as a consequence of alterations at the level of gene function, and that are relevant to basic neuroscience and to animal models of neurological and psychiatric disorders. Current Research Behavioral testing within the center involves a collaborative component in which mice provided by users are assessed for behavioral/cognitive functions. All research includes behavioral assessment of a variety of genetically altered mice provided by users. Services Provided The objective of the center is to provide a link between genetic and molecular analysis of neural function and the study of integrative systems and clinical conditions through behavioral assessment of animal models, and mouse behavioral phenotypes generated by genetic modification. Sponsors: This resource is supported by the National Center of Research Resources (Grant Number: P40 RR017688). | function, gene, animal, behavioral, clinical, cognitive, disorder, model, mouse, neural, neurological, neuroscience, phenotype, psychiatric, testing | has parent organization: Johns Hopkins University; Maryland; USA | Free, Freely available | nif-0000-25310 | SCR_002851 | NBC | 2026-08-03 09:32:03 | 0 | ||||||||
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Computational Biology Center Resource Report Resource Website 50+ mentions |
Computational Biology Center (RRID:SCR_002877) | portal, disease-related portal, topical portal, data or information resource, training resource | Computational biology research at Memorial Sloan-Kettering Cancer Center (MSKCC) pursues computational biology research projects and the development of bioinformatics resources in the areas of: sequence-structure analysis; gene regulation; molecular pathways and networks, and diagnostic and prognostic indicators. The mission of cBio is to move the theoretical methods and genome-scale data resources of computational biology into everyday laboratory practice and use, and is reflected in the organization of cBio into research and service components ~ the intention being that new computational methods created through the process of scientific inquiry should be generalized and supported as open-source and shared community resources. Faculty from cBio participate in graduate training provided through the following graduate programs: * Gerstner Sloan-Kettering Graduate School of Biomedical Sciences * Graduate Training Program in Computational Biology and Medicine Integral to much of the research and service work performed by cBio is the creation and use of software tools and data resources. The tools that we have created and utilize provide evidence of our involvement in the following areas: * Cancer Genomics * Data Repositories * iPhone & iPod Touch * microRNAs * Pathways * Protein Function * Text Analysis * Transcription Profiling | drug, evolution, experiment, gene, algorithm, bioinformatics, biology, cancer, clinical, computational, diagnostic, genome, human, initiation, kinetics, laboratory, leukemia, ligand, metastasis, microrna, mirna, model, molecular, network, pathway, phenotype, prognostic, progression, protein, regulation, research, resistance, rna, sequence, stem cell, structure, t cell, therapy, treatment, tumor | is parent organization of: TMBETA-GENOME- Annotation of Beta-Barrel Membrane Proteins in Genomic Sequences | Free, Freely available | nif-0000-25560 | SCR_002877 | cBio | 2026-08-03 09:32:09 | 70 | ||||||||
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International Spinal Cord Society Resource Report Resource Website 10+ mentions |
International Spinal Cord Society (RRID:SCR_002908) | topical portal, data or information resource, portal | ISCoS promotes the highest standard of care in the practice of spinal cord injury for men, women and children throughout the world. Through its medical and multi disciplinary team of Professionals ISCoS endeavours to foster education, research and clinical excellence. ISCoS has a membership of over 1,000 Clinicians and Scientists from 87 countries. They regularly update their knowledge at the Annual Scientific Meeting held in a different country each year. Goals of ISCoS: :- Serve as an international impartial, non-political and non-profit making association whose purpose is to study all problems relating to traumatic and non-traumatic lesions of the spinal cord. This includes causes, prevention, basic and clinical research, medical and surgical management, clinical practice, education, rehabilitation and social reintegration. This society will function in close collaboration with other national and international bodies, thereby encouraging the most efficient use of available resources. :- Provide a scientific exchange among its members and others by collecting and disseminating information through publications, correspondence, exhibits, regional and international seminars, symposia, conferences and otherwise. :- Advise, encourage, promote and when requested, assist in efforts to co-ordinate or guide research, development and evaluation activities related to spinal cord lesions throughout the world. :- Advise, encourage, guide and support the efforts of those responsible for the care of patients involved and when requested, correlate these activities throughout the world. :- Advise, encourage, guide and support the efforts of those responsible for the education and training of medical professionals and professionals allied to medicine and when requested, correlate these activities throughout the world. | education, clinical, medical, rehabitation, research, society, spinal cord, surgical | nif-0000-30009 | SCR_002908 | ISCoS | 2026-08-03 09:31:53 | 18 | ||||||||||
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Northwestern University Schizophrenia Data and Software Tool (NUSDAST) Resource Report Resource Website |
Northwestern University Schizophrenia Data and Software Tool (NUSDAST) (RRID:SCR_014153) | NUSDAT | image collection, data or information resource, database | A repository of schizophrenia neuroimaging data collected from over 450 individuals with schizophrenia, healthy controls and their respective siblings, most with 2-year longitudinal follow-up. The data include neuroimaging data, cognitive data, clinical data, and genetic data. | database, neuroimaging, clinical, cognitive, genetic, schizophrenia, longitudinal |
uses: CAWorks is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC) has parent organization: Northwestern University; Illinois; USA |
Schizophrenia | NIMH 1R01 MH084803; NIMH 1U01 MH097435; NIMH P50 MH071616; NIMH R01 MH056584; NCRR P41 RR15241; NIGMS U24 GM104203; NIH Bio-Informatics Research Network Coordinating Center |
Available to the research community | SCR_014153 | Northwestern University Schizophrenia Data and Software Tool | 2026-08-03 09:35:31 | 0 | ||||||
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Clinical Islet Transplantation Consortium (CITC) Resource Report Resource Website 1+ mentions |
Clinical Islet Transplantation Consortium (CITC) (RRID:SCR_014385) | CITC, CIT | access service resource, service resource | Network of clinical centers and a data coordinating center established to conduct studies of islet transplantation in patients with type 1 diabetes. | type 1 diabetes, consortium, network, islet transplantation, clinical |
is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Research Resources is listed by: Diabetes Research Centers |
Type 1 diabetes, Diabetes | NIDDK U01 DK070431; NIAID |
SCR_014385 | Clinical Islet Transplantation Consortium | 2026-08-03 09:35:42 | 1 | |||||||
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GVKBIO databases Resource Report Resource Website 1+ mentions |
GVKBIO databases (RRID:SCR_014893) | data or information resource, software resource, database, web application | Collection of databases with standalone databases, which gives opportunity for customers to integrate the data into their internal tools and databases, as well as online databases, that are available to the customers from a dedicated website where an individual can query and export the data in the selected format. The standalone database topics include medicinal chemistry, drugs and target class based compounds. The online databases are comprised of three major compilations: GVK BIO Online Structure Activity Relation Database (GOSTAR), GVK BIO Biomarker Database (GOBIOM), and Clinical Trial Outcome Database (CTOD). | research, database, online, standalone, medicinal chemistry, drug, clinical, toxicity, biomarker, contract research organization, cro | Commercial | SCR_014893 | GVK Biosciences, GVK BIO | 2026-08-03 09:35:55 | 2 | ||||||||||
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International Initiative for Traumatic Brain Injury Research Resource Report Resource Website 1+ mentions |
International Initiative for Traumatic Brain Injury Research (RRID:SCR_016237) | InTBIR | access service resource, service resource | Project whose goal is to improve health care and lessen the global burden of TBI through the discovery of causal relationships between treatments and clinically meaningful outcomes. InTBIR seeks to encourage well-designed, hypothesis-driven studies that include the collection of high quality data followed by rigorous statistical analysis. | tbi, traumatic, brain, injury, neurology, neuroscience, neuroanatomy, medical, clinical, research, nih |
has parent organization: European Commission has parent organization: Canadian Institutes of Health Research |
SCR_016237 | International Initiative for Traumatic Brain Injury Research (InTBIR) | 2026-08-03 09:36:19 | 4 | |||||||||
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L1000 Fireworks Display Resource Report Resource Website 10+ mentions |
L1000 Fireworks Display (RRID:SCR_016175) | L1000FWD | software application, data processing software, web application, software resource, data visualization software | Web application that provides interactive visualization of drug and small-molecule induced gene expression signatures. L1000FWD enables coloring of signatures by different attributes such as cell type, time point, concentration, as well as drug attributes such as MOA and clinical phase. | drug, small molecule, gene, expression, signature, moa, clinical, phase | has parent organization: Icahn School of Medicine at Mount Sinai; New York; USA | PMID:29420694 | Freely available, Free, Available for download | SCR_016175 | L1000FWD: Large-scale Visualization of Drug-Induced Transcriptomic Signatures | 2026-08-03 09:36:18 | 14 | |||||||
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Canadian Open Neuroscience Platform Resource Report Resource Website 1+ mentions |
Canadian Open Neuroscience Platform (RRID:SCR_016433) | CONP | organization portal, data repository, portal, service resource, storage service resource, data or information resource | Web interface that facilitates open science for neuroscience community by simplifying global access to and sharing of datasets and tools. Portal internalizes typical data cycle of research project, beginning with data acquisition, followed by data processing with published tools, and ultimately publication of results with link to original dataset. Platform to form interactive network of collaborations in brain research, interdisciplinary student training, international partnerships, clinical translation and open publishing. Provides unified interface to Canadian neuroscience research community. Open neuroscience research with sharing of both data and methods, to create large-scale databases, development of standards for sharing, facilitation of advanced analytic strategies, open dissemination to global community of neuroscience data and methods, and establishment of training programs for next generation of computational neuroscience researchers. | interactive, network, brain, research, interdisciplinary, student, training, international, partnership, clinical, translation, open, publishing, Canada |
is related to: Brain Canada is related to: Health Canada |
Open source | r3d100013461 | https://github.com/CONP-PCNO/conp-portal, https://doi.org/10.17616/R31NJMVP | SCR_016433 | CONP:Canadian Open Neuroscience Platform | 2026-08-03 09:36:46 | 9 | ||||||
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FCS Express Resource Report Resource Website 100+ mentions |
FCS Express (RRID:SCR_016431) | software resource, data processing software, software application, data analysis software | Software tool for flow and image cytometry data analysis by De Novo Software company. | flow, image, analysis, data, cytometry, De Novo Software, research, clinical, laboratory | is listed by: SoftCite | Commercially available, Tutorial available | SCR_016431 | 2026-08-03 09:36:22 | 488 | ||||||||||
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NINDS Disorder Index Resource Report Resource Website |
NINDS Disorder Index (RRID:SCR_000433) | NINDS Disorder Index, NINDS Disorder List | data or information resource, data set | Reference disease data set of neurological diseases along with their definitions, etiology, treatment, prognosis, ongoing research, clinical trials information and publications. The Disorder Index includes synonyms and research topics. Navigation is by letter of the alphabet., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. | genetic disorder, disease, disease progression, disorder, neurological disease, bibliography, clinical |
is used by: NIF Data Federation is related to: Integrated Disease has parent organization: National Institute of Neurological Disorders and Stroke |
THIS RESOURCE IS NO LONGER IN SERVICE | nif-0000-23200 | SCR_000433 | NINDS Disease List, Disorder Index: National Institute of Neurological Disorders and Stroke (NINDS), Disorders index from the National Institute of Neurological Disorders and Stroke (NINDS), NINDS Disorders A - Z, National Institute of Neurological Disorders and Stroke Disorder Index | 2026-08-03 09:31:02 | 0 | |||||||
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Center for In Vivo Microscopy Resource Report Resource Website 10+ mentions |
Center for In Vivo Microscopy (RRID:SCR_001426) | CIVM | training resource, biomedical technology research center | Biomedical technology research center dedicated to the development of novel imaging methods for the basic scientist and the application of the methods to important biomedical questions. The CIVM has played a major role in the development of magnetic resonance microscopy with specialized MR imaging systems capable of imaging at more than 500,000x higher resolution than is common in the clinical domain. The CIVM was the first to demonstrate MR images using hyperpolarized 3He which has been moved from mouse to man with recent clinical trials performed at Duke in collaboration with GE. More recently the CIVM has developed the molecular imaging workbench---a system dedicated to multimodality cardiopulmonary imaging in the rodent. Their collaborators are employing these unique imaging systems in an extraordinary range of mouse and rat models of neurologic disease, cardiopulmonary disease and cancer to illuminate the underlying biology and explore new therapies. | imaging, magnetic resonance microscopy, magnetic resonance imaging, clinical, mri, ct, x-ray, ultrasound, confocal, optical, spect | has parent organization: Duke University; North Carolina; USA | Cardiopulmonary disease, Cancer, Neurological disease | NIBIB 4P41EB015897-27 | Free, Freely Available | nlx_152650 | SCR_001426 | Duke Center for In Vivo Microscopy | 2026-08-03 09:31:22 | 10 | |||||
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National Center for Image-Guided Therapy Resource Report Resource Website 1+ mentions |
National Center for Image-Guided Therapy (RRID:SCR_001419) | NCIGT | training resource, biomedical technology research center | Biomedical Technology Resource Center that serves as a national resource for all aspects of research into medical procedures that are enhanced by imaging. Its common goal is to provide more effective patient care. The center is focused on the multidisciplinary development of innovative image-guided intervention technologies to enable effective, less invasive clinical treatments that are not only more economical, but also produce better results for patients. The NCIGT is helping to implement this vision by serving as a proving ground for some of the next generation of medical therapies. | clinical, patient care, imaging, medical procedure | has parent organization: Harvard Medical School; Massachusetts; USA | NIBIB P41EB015898 | Free, Freely Available | nlx_152641 | SCR_001419 | National Center for Image Guided Therapy | 2026-08-03 09:31:22 | 2 | ||||||
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fMRI Research Center at Columbia Resource Report Resource Website 10+ mentions |
fMRI Research Center at Columbia (RRID:SCR_002658) | PICS | service resource, access service resource, core facility | THIS RESOURCE IS NO LONGER IN SERVICE, documented on 7/28/13. Core facility of Columbia Neuroscience with the goal of establishing a collaborative and multi-investigator neuroimaging environment that is focused on the investigation of the neurocircuitry of the brain that underlies cognition, perception and action, and also the development of clinical applications that enhance the goals of personalized medicine. Within this environment the specific current research interests of the Hirsch group include several related directions of investigation. The first is conscious and subconscious neural processes that mediate emotion and cognition in healthy individuals and in patients with psychiatric disorders. This direction also includes neurocircuitry that is characteristic of disorders of consciousness such as minimally conscious or vegetative states, self and visual awareness, and attention. Neurocircuitry of other complex cognitive processes such as decisions, inductive and deductive reasoning, language, truthfulness and top-down influences of expectation, reward, and regulation on early visual and mid-level perceptual and emotional systems. On-going projects targeted for clinical applications include benefits for neurosurgery such as the development of task batteries to map the cortical locations of essential functions such as language, motor, sensation, memory, emotion and sensory functions including visions, audition and the chemical senses. Computational innovations for labeling correspondence between brain structure and specific functional regions are under development to achieve the highest interpretive precision. Current projects include integration of EEG and fMRI techniques to localize seizuregenic cortex in relation to eloquent and functioning cortex for neurosurgical planning; integration of TMS and fMRI to discriminate essential and associative language-sensitive cortical areas; and integration of VEP, EEG and fMRI to inform assessments of visual disease secondary to stroke or neural degeneration. Projects intended to refine and enhance diagnosis of psychiatric disorders such as anxiety, depression, and eating disorders include development of specialized paradigms to target dysfunctional neurocircuitry such as emotional systems (amygdala and basal ganglia) and control and regulatory systems (cingulate and pre-frontal cortex). Comparison of before-treatment images with after-treatment images to inform models of both treatment and disease and investigation of the hypothesis that individual genetic and functional differences have predictive value for treatment options and outcome are currently underway. The lab has pioneered techniques for functional mapping of single patients, and operates an active clinical service for mapping individuals for neurosurgical planning, assessments of the neurocircuitry that underlie acquired or inherited disabilities and the mechanisms of neuroplasticity that restore lost functions are actively investigated using both groups and single subject studies. : | fmri, imaging, neuroscience, cognitive sciences, cognition, perception, action, clinical, personalized medicine, neuroimaging, neurocircuitry, brain, vep, eeg | has parent organization: Columbia University; New York; USA | THIS RESOURCE IS NO LONGER IN SERVICE | nif-0000-00405 | SCR_002658 | Program for Imaging and Cognitive Sciences, Program for Imaging & Cognitive Sciences | 2026-08-03 09:31:57 | 40 | |||||||
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Family Investigation of Nephropathy of Diabetes Resource Report Resource Website |
Family Investigation of Nephropathy of Diabetes (RRID:SCR_001525) | FIND, F.I.N.D. | resource, clinical trial | Multicenter observational study designed to identify genetic determinants of diabetic nephropathy. It is conducted in eleven U.S. clinical centers and a coordinating center, and with four ethnic groups (European Americans, African Americans, Mexican Americans, and American Indians). Two strategies are used to localize susceptibility genes: a family-based linkage study and a case-control study using mapping by admixture linkage disequilibrium (MALD). In the family-based study, probands with diabetic nephropathy are recruited with their parents and selected siblings. Linkage analyses will be conducted to identify chromosomal regions containing genes that influence the development of diabetic nephropathy or related quantitative traits such as serum creatinine concentration, urinary albumin excretion, and plasma glucose concentrations. Regions showing evidence of linkage will be examined further with both genetic linkage and association studies to identify genes that influence diabetic nephropathy or related traits. Two types of MALD studies are being done. One is a case-control study of unrelated individuals of Mexican American heritage in which both cases and controls have diabetes, but only the case has nephropathy. The other is a case-control study of African American patients with nephropathy (cases) and their spouses (controls) unaffected by diabetes and nephropathy; offspring are genotyped when available to provide haplotype data. The specific goals of this program: * Delineate genomic regions associated with the development and progression of renal disease(s) * Evaluate whether there is a genetic link between diabetic nephropathy and diabetic retinopathy * Improve outcomes * Provide protection for people at risk and slow the progression of renal disease * Help establish a resource for genetic studies of kidney disease and diabetic complications by creating a repository of genetic samples and a database * Encourage studies of the genetics of progressive renal disease | genetic susceptibility, genetic pathway, renal, kidney, outcome, gene, genetics, european-american, african-american, mexican-american, american-indian, linkage association study, admixture linkage disequilibrium, mapping by admixture linkage disequilibrium, serum creatinine, urinary protein excretion, plasma glucose level, blood pressure, blood lipid level, trait, linkage, adult human, male, female, clinical |
is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases |
NIDDK 5R01DK053591 | PMID:15642484 | Free, Freely available | nlx_152825 | https://www.niddkrepository.org/studies/find/ | SCR_001525 | Family Investigation of Nephropathy and Diabetes (F.I.N.D.), Family Investigation of Nephropathy & Diabetes | 2026-08-03 09:31:25 | 0 |
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