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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
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BrainVoyager: Talairach Brain Atlas Resource Report Resource Website |
BrainVoyager: Talairach Brain Atlas (RRID:SCR_008800) | BV Talairach Brain Atlas | data or information resource, data processing software, talairach-tournoux atlas, reference atlas, software application, data visualization software, atlas, software resource | The Talairach brain atlas visualized via BrainVoyager (Commercial software) can be used to visualize Brodmann areas as they were defined for the Talairach brain (Talairach & Tournaux, 1988) and to compare regions of subjects with respect to the Brodmann areas. The demarcated areas are based on the Talairach demon, which is a digitized version of the Talairach atlas and which has been transferred into BrainVoyager VOI files by Matthias Ruf, Mannheim. Using the Brodman.voi file you may ask questions like the following: What is the signal time course of subject N in experiment A within Brodmann area X ?. Note, however, that the defined areal boundaries should be used only as a rough guideline for determining the location of activated regions: There is substantial variation of histologically defined areas between subjects. Since cytoarchitectonically defined Brodmann areas are not available in vivo, we advise to use the provided information with care. The TalairachBrain.vmr file is located in the same folder as your BrainVoyager executable file. It can be loaded as any VMR project by using the Open... item in the File menu (or the Open icon). The TalairachBrain.vmr file is also loaded automatically when using the glass brain visualization tool. | brodmann partition scheme, cerebral cortex, human, brain, talairach | has parent organization: BrainVoyager | nlx_144323 | SCR_008800 | 2026-08-13 09:27:59 | 0 | |||||||||
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Cambridge Neuroscience Department Resource Report Resource Website 1+ mentions |
Cambridge Neuroscience Department (RRID:SCR_008649) | data or information resource, organization portal, department portal, portal | This portal provides information about the neuroscience department at the University of Cambridge. Cambridge has a strong tradition in neuroscience having been host to the first analyses of neural signaling in the 1930s, determined the mechanisms of neuronal firing in the 1950s, and heralded some of the early theoretical approaches to the functions of neural circuitry in the 1960s. Neuroscience continues to grow at Cambridge, with an impressive record of achievement in multidisciplinary research. | education, analysis, circuitry, department, graduate, mechanism, neural, neuron, neuronal, neuroscience, research, signaling, theoretical, undergraduate | has parent organization: University of Cambridge; Cambridge; United Kingdom | nif-0000-33002 | SCR_008649 | Cambridge Neuroscience | 2026-08-13 09:27:55 | 1 | |||||||||
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MoonProt Resource Report Resource Website 10+ mentions |
MoonProt (RRID:SCR_008803) | data or information resource, organization portal, laboratory portal, portal | The moonlighting protein database is not yet available publicly. Stay tuned. Moonlighting proteins have multiple, seemingly unrelated functions not due to gene fusions or alternative splicing. Like PGI, which is a cytosolic enzyme and an extracellular cytokine, dozens of other proteins have been found to moonlight. Connie coined the term moonlighting proteins and has written several review articles that develop the idea of moonlighting proteins and describe additional moonlighting proteins from the literature, how they switch between functions, how they might have evolved, and how they might benefit the cell. She is currently writing two additional invited articles and planning computational studies of the sequences and structures of known moonlighting proteins. | protein, multifunctional protein, double functional protein, protein database | has parent organization: University of Illinois at Chicago; Illinois; USA | PMID:12902157 | nlx_144357 | SCR_008803 | Moonlighting proteins database | 2026-08-13 09:28:00 | 27 | ||||||||
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The NeuroScience Network Resource Report Resource Website 100+ mentions |
The NeuroScience Network (RRID:SCR_008648) | topical portal, data or information resource, portal | THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. An initiative to build connections among the many powerful resources across the region. Between colleges and universities, pharmaceutical and biotechnology companies, device developers, startups and service businesses, the Cure Corridor, Einsteins''s Alley, the Pharm Belt, or whatever you like to call the region, offers opportunities for discovery and development of new therapies that is unmatched. Sponsors: The NeuroScience Network is made possible, in part, through funding from Bio 1 WIRED. | biotechnology, college, connection, network, neuroscience, pharmaceutical, university | THIS RESOURCE IS NO LONGER IN SERVICE | nif-0000-32997 | SCR_008648 | NeuroScience Network | 2026-08-13 09:27:57 | 107 | |||||||||
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Taub Institute for Research on Alzheimers Disease and the Aging Brain Resource Report Resource Website |
Taub Institute for Research on Alzheimers Disease and the Aging Brain (RRID:SCR_008802) | material resource, brain bank, tissue bank, biomaterial supply resource | An institute which conducts research of Alzheimer's, Parkinson's and other age-related brain diseases. This organization also provides clinical evaluations to patients with memory problems, Alzheimer's disease or other types of dementia. Furthermore, the institute leads multi-center clinical trials for the treatment and prevention of Alzheimer's, Parkinson's and other age-related brain diseases. There is a brain donation program for enrolled/examined patients. The Education Core of the Taub Institute sponsors community events and Continuing Medical Education programs, as well as the distribution of periodic newsletters and brochures highlighting research developments and other Alzheimer's topics. | alzheimer's disease, parkinson's disease, age-related brain disease, neurodegenerative disease, late adult human, frontotemporal lobar degeneration, lewy body dementia, vascular disease, metabolic disease, geriatric psychiatry, normal aging, autopsy, brain tissue, brain, tissue, imaging, clinical trial, cell biology, neuroscience, cognitive neuroscience |
is listed by: One Mind Biospecimen Bank Listing has parent organization: Columbia University; New York; USA |
Alzheimer's disease, Parkinson's disease, Age-related brain disease, Neurodegenerative disease, Frontotemporal lobar degeneration, Lewy body dementia, Vascular disease, Metabolic disease, Aging | NIA ; Taub Family Foundation |
nlx_144343 | SCR_008802 | Taub Institute ADRC, Taub Center for Alzheimer's Disease Research, Taub Institute Alzheimer's Disease Research Center, Taub Institute for Research on Alzheimer’s Disease | 2026-08-13 09:27:56 | 0 | |||||||
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Massachusetts Alzheimer's Disease Research Center Resource Report Resource Website 1+ mentions |
Massachusetts Alzheimer's Disease Research Center (RRID:SCR_008764) | MADRC, ADRC | material resource, brain bank, tissue bank, biomaterial supply resource | An Alzheimer's disease research center which supports new research and enhances ongoing research by providing core support to bringing together behavioral, biomedical, and clinical scientists. The Center conducts multidisciplinary research, trains scientists, and spreads information about Alzheimer's disease and related disorders to the general public. The principal goal of the Massachusetts ADRC is to support research in aging, Alzheimer's Disease and other related disorders. Researchers work with national and international multi-disciplinary teams to understand: normal aging, the transition from normal aging to mild forms of memory problems, and the later stages of dementia. The Massachusetts ADRC has an active brain donation program at the Massachusetts General Hospital (MGH) for patients as well as subjects enrolled in research studies. | brain, tissue, healthy control, alzheimer's disease, neurological disease, parkinson's disease, frontotemporal dementia, dementia with lewy bodies, dementia, neurodegenerative disease |
is listed by: One Mind Biospecimen Bank Listing has parent organization: Harvard Medical School; Massachusetts; USA |
Aging, Alzheimer's disease, Neurological disease, Parkinson's disease, Frontotemporal dementia, Pick's disease, Primary Progressive Aphasia, Dementia with Lewy bodies, Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Vascular dementia, Cerebral Amyloid Angiopathy, Dementia pugilistica, Boxer's Syndrome, Neurodegenerative disease | U.S. Department of Health and Human Services ; NIA |
Public, Available to the research community | nlx_144104 | SCR_008764 | Massachusetts ADRC, Massachusetts Alzheimer's Disease Research Center | 2026-08-13 09:27:59 | 1 | |||||
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Rush Alzheimer's Disease Center Resource Report Resource Website 1+ mentions |
Rush Alzheimer's Disease Center (RRID:SCR_008763) | RADC | material resource, brain bank, tissue bank, biomaterial supply resource | An Alzheimer's disease center which researches the cause, treatment and prevention of Alzheimer's disease with a focus on four main areas of research: risk factors for Alzheimer's and related disorders, the neurological basis of the disease, diagnosis, and treatment. Data includes a number of computed variables that are available for ROS, MAP and MARS cohorts. These variables are under categories such as affect and personality, chronic medical conditions, and clinical diagnosis. Specimens include ante-mortem and post-mortem samples obtained from subjects evaluated by ROS, MAP and clinical study cores. Specimen categories include: Brain tissue (Fixed and frozen), Spinal cord, Muscles (Post-mortem), and Nerve (Post-mortem), among other types of specimens. Data sharing policies and procedures apply to obtaining ante-mortem and post-mortem specimens from participants evaluated by the selected cohorts of the RADC. | clinical, post mortem, ante mortem, late adult human, brain, tissue, spinal cord, muscle, nerve, dna, lymphocyte, serum, plasma, urine, fixed, frozen, cryopreserved, alzheimer's disease, memory | is listed by: One Mind Biospecimen Bank Listing | Alzheimer's disease, Alzheimer's-related disorder, Aging | NIA | Available to the research community, Data sharing policies apply to both data and specimens | nlx_144050 | SCR_008763 | Rush ADC, Rush Alzheimer's Disease Center | 2026-08-13 09:27:56 | 3 | |||||
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Sanders Brown Center on Aging Resource Report Resource Website 1+ mentions |
Sanders Brown Center on Aging (RRID:SCR_008765) | SBCoA | topical portal, data or information resource, portal | A center which focuses on research dedicated to the aging process and age-related brain diseases, as well as education, outreach, and clinical programs that promote healthy brain aging. The major foci of the Center are basic and applied research in Alzheimer's disease and related neurodegenerative disorders. Its objectives include expanding translational neuroscience research and providing educational opportunities to the general public, as well as healthcare students and professionals., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. | alzheimer's disease, neurodegenerative disease, traumatic brain injury, aging process translational neuroscience |
has parent organization: University of Kentucky; Kentucky; USA is parent organization of: University of Kentucky Alzheimer's Disease Center |
Aging, Alzheimer's disease, Neurodegenerative disease | THIS RESOURCE IS NO LONGER IN SERVICE | nlx_144055 | SCR_008765 | Sanders-Brown Center on Aging | 2026-08-13 09:27:59 | 1 | ||||||
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Transgenic Hydra Facility Resource Report Resource Website 1+ mentions |
Transgenic Hydra Facility (RRID:SCR_008641) | biomaterial supply resource, material resource, organism supplier | The Transgenic Hydra Facility is a non-profit facility in the laboratory of Thomas Bosch at the University of Kiel that assists scientists to use and to develop transgenic Hydra polyps. Our mission is to provide investigators access to the latest technology for the efficient production of transgenic polyps. We particularly encourage scientists from laboratories lacking the infrastructure for transgenic Hydra technologies to use our services. Abstract: Understanding the evolution of development in large part relies on the study of phylogenetically old organisms. Cnidarians, such as Hydra, have become attractive model organisms for these studies. However, despite long-term efforts, stably transgenic animals could not be generated, severely limiting the functional analysis of genes. Here we report the efficient generation of transgenic Hydra lines by embryo microinjection. One of these transgenic lines expressing EGFP revealed remarkably high motility of individual endodermal epithelial cells during morphogenesis. We expect that transgenic Hydra will become important tools to dissect the molecular mechanisms of development at the base of the Metazoan tree. Sponsors: Financial support for this research was provided by the German Research Foundation [Deutsche Forschungsgemeinschaft Grants B0848/13 and SFB617. | has parent organization: University of Kiel; Schleswig-Holstein; Germany | nif-0000-32040 | SCR_008641 | Transgenic Hydra | 2026-08-13 09:27:58 | 1 | ||||||||||
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FigTree Resource Report Resource Website 10000+ mentions |
FigTree (RRID:SCR_008515) | data processing software, software resource, data visualization software, software application | A graphical viewer of phylogenetic trees and a program for producing publication-ready figures. It is designed to display summarized and annotated trees produced by BEAST. | data visualization software, graphical viewer, phylogenetic tree, annotate |
is listed by: Debian is listed by: OMICtools is listed by: SoftCite has parent organization: University of Edinburgh; Scotland; United Kingdom |
OMICS_04268, nif-0000-30567 | https://sources.debian.org/src/figtree/ | SCR_008515 | FigTree | 2026-08-13 09:27:55 | 12345 | ||||||||
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NYU Alzheimer's Disease Center Resource Report Resource Website |
NYU Alzheimer's Disease Center (RRID:SCR_008754) | NYU ADC | material resource, brain bank, tissue bank, biomaterial supply resource | The NYU Alzheimer's Disease Center is part of the Department of Psychiatry at New York University School of Medicine. The center's goals are to advance current knowledge and understanding of brain aging and Alzheimer's disease, to expand the numbers of scientists working in the field of aging and Alzheimer's research, to work toward better treatment options and care for patients, and to apply and share its findings with healthcare providers, researchers, and the general public. The ADC's programs and services extend to other research facilities and to healthcare professionals through the use of its core facilities. The NYU ADC is made up of seven core facilities: Administrative Core, Clinical Core, Neuropathology Core, Education Core, Data Management and Biostatistics Core, Neuroimaging Core, and Psychosocial Core. | brain, tissue, alzheimer's disease, dementia, meeting resource, clinical, imaging, neuroimaging, psychosocial, post-mortem, autopsy, vaccination, treatment |
is listed by: One Mind Biospecimen Bank Listing has parent organization: New York University School of Medicine; New York; USA |
Alzheimer's disease, Dementia, Aging | NIA | Available to collaborators | nlx_144383 | http://www.med.nyu.edu/adc/ | SCR_008754 | NYU Alzheimer's Disease Center, New York University Alzheimer's Disease Center | 2026-08-13 09:27:55 | 0 | ||||
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Aquatic Habitats Resource Report Resource Website 1+ mentions |
Aquatic Habitats (RRID:SCR_008597) | production service resource, service resource, biomaterial manufacture, material service resource |
Aquatic Habitats (AHAB) is the worlds largest manufacturer of housing systems for aquatic research animals. We are biologists first and engineers second, so we understand the complexity of aquatic life and how to sustain it. Our turnkey systems are secure, efficient and as fail-safe as possible. |
nif-0000-31933 | http://www.marinebiotech.com/ | SCR_008597 | AHAB | 2026-08-13 09:27:54 | 8 | ||||||||||
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Evidence Based Toxicology Resource Report Resource Website 1+ mentions |
Evidence Based Toxicology (RRID:SCR_008507) | data or information resource, organization portal, department portal, portal | This website is an invitation. an invitation to join scientists and stakeholders in an effort to review the scientific basis of traditional toxicological risk assessment, to provide the toxicological community with the tools it needs to efficiently and transparently judge risks of a diversifying nature and to make toxicology thus fit to meet the challenges of the 21st century. an invitation to participate in the inception and continuous implementation of a new movement in toxicology that aims at adopting an evidence-based approach. an invitation to help bridging the gap between modern toxicological science and risk assessment in order to exploit the wealth of information from new technologies in modern life sciences & toxicological research and to arrive at informed, transparent, judicious and conscientious decisions made on the basis of all evidence available. an invitation to develop a framework that allows combining precious expert insight grown over years of practical experience with structured approaches in basic science, in method assessment and in decision-making. Such evidence-based toxicology might help to make the best possible use of all sources of evidence in an efficient, productive, reliable, acceptable and transparent manner. Why do we need evidence-based toxicology (EBT)? Toxicology and the delivery of effective safety assessment critically relies on concepts and understanding generated by basic scientific research and must therefore adapt constantly to advances in knowledge. However, particularly from the perspective of regulatory toxicology, some of the assessment paradigms and methodologies were established decades ago and have changed little in response to scientific progress. At the same time, changes in our understanding of human disease, changes in the types of product now requiring safety assessment, and changes in the legislative landscape and public expectations pose significant challenges for industry, academia and regulators alike. It is necessary to challenge the status quo and ensure that as a matter of course best scientific practice and technical sophistication is reflected in safety assessment practices such that current and future challenges can be met. It is important therefore to ensure that structures are available that will encourage, facilitate and support a process of critical appraisal and renewal of the toxicological repertoire available for safety assessment. Part of this process is to embrace evidence-based toxicology such that the best possible scientific evidence is applied to judge product safety and likely risks to human health. | nif-0000-30537 | SCR_008507 | EBT | 2026-08-13 09:27:55 | 9 | |||||||||||
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Layton Center NeuroImaging Laboratory Resource Report Resource Website 1+ mentions |
Layton Center NeuroImaging Laboratory (RRID:SCR_008823) | data or information resource, organization portal, image collection, analysis service resource, production service resource, laboratory portal, service resource, data analysis service, portal | NeuroImaging laboratory focused on detecting early brain changes associated with cognitive decline and dementia that manages the neuroimaging component of all studies at the Layton Aging and Alzheimer's Center including acquisition and archival services, as well as volumetric analysis of anonymized MRI scans. Assistance with resulting data is also available, including statistical analysis, and preparation of materials for presentation and publication. The Layton Center also manages a library of thousands of digitized MRI scans, including what is believed to be the largest collection of longitudinal MRI scans of cognitively intact elderly subjects. The OADC Neuroimaging Lab conducts MRI studies on both 3 and 7T MRI systems using advanced sequences, employing a multimodal approach to brain imaging research. | normal, mri, magnetic resonance imaging assay, neuroimaging, brain, longitudinal, late adult human | has parent organization: OHSU Layton Aging and Alzheimer's Disease Center | Aging, Alzheimer's disease, Cognitive decline, Cognitively intact, Dementia | NIA | nlx_144447 | SCR_008823 | Layton Aging and Alzheimer's Center NeuroImaging Laboratory, Layton Aging & Alzheimer's Disease Center Neuro-Imaging Lab, Layton Aging Alzheimer's Disease Center Neuro-Imaging Lab, Layton Center Neuro-Imaging Lab, Layton Aging and Alzheimer's Disease Center Neuro-Imaging Lab, Layton Aging and Alzheimer's Center Neuro-Imaging Lab | 2026-08-13 09:28:00 | 1 | |||||||
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Research Blogging Resource Report Resource Website 1+ mentions |
Research Blogging (RRID:SCR_008786) | Research Blogging | data or information resource, blog, narrative resource, service resource | Aggregator of blogs about new developments in science and other fields that allows readers to easily find blog posts about serious peer-reviewed research, instead of just news reports and press releases. If you''re a blogger who writes about serious research, Research Blogging offers you a way to distinguish your serious posts from news, politics, family, bagpipes, and so on. They can direct your regular readers - and new readers - to the posts you''ve worked the hardest to create. All you need to get started is a blog and a peer-reviewed research report that you''d like to discuss. How it works * Bloggers -- often experts in their field -- find exciting new peer-reviewed research they''d like to share. They write thoughtful posts about the research for their blogs. * Bloggers register and use a simple one-line form to create a snippet of code to place in their posts. This snippet not only notifies this site about their post, it also creates a properly formatted research citation for their blog. * Their software automatically scans registered blogs for posts containing their code snippet. When it finds them, it indexes them and displays them on their front page -- thousands of posts from hundreds of blogs, in one convenient place, organized by topic. * Their editors identify the notable posts in each major discipline, publishing the results on their news page. * Other services like PubGet index their database as well, so every time readers search for a journal article, they can also locate blog posts discussing the article. * The quality of the posts listed on their site is monitored by the member bloggers. If a post doesn''t follow their guidelines, it is removed from their database. Borderline cases may be discussed publicly on the blog as well. Bloggers are also provided with an icon they can use to show when they''re talking about a peer-reviewed work that they''ve read and analyzed closely. There are already over seven thousand blog posts using the icon, and now it''s easier than ever to find them. | aggregator, peer-reviewed research, database, science, anthropology, astronomy, biology, chemistry, computer science, engineering, ecology, conservation, geoscience, health, mathematics, medicine, neuroscience, philosophy, physics, psychology, social science, research, scholarship |
is used by: NIF Data Federation is used by: Integrated Blogs |
Free, Non-commercial, Commercial purposes with written authorization. | nlx_144211 | SCR_008786 | ResearchBlogging.org | 2026-08-13 09:27:59 | 5 | |||||||
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Brain Facts Resource Report Resource Website |
Brain Facts (RRID:SCR_008788) | Brain Facts | narrative resource, book, training material, data or information resource | Brain Facts is a 74-page primer on the brain and nervous system, published by SfN. Designed for a lay audience as an introduction to neuroscience, Brain Facts is also a valuable educational resource used by high school teachers and students who participate in Brain Awareness Week. The 2008 edition updates all sections and includes new information on brain development, learning and memory, language, neurological and psychiatric illnesses, potential therapies, and more. Download the full book (PDF) or download individual sections. All downloads are PDFs. Educators, request a copy of the Brain Facts book (paperback or CD) - contact [email protected]. | k-12, brain, nervous system, brain development, learning, memory, language, neurological illness, psychiatric illness, therapy, movement, sleep, stress, neuron, sensation, perception, neuroethics | has parent organization: Society for Neuroscience | Aging | nlx_144227 | SCR_008788 | Brain Facts - A Primer on the Brain and Nervous System | 2026-08-13 09:27:59 | 0 | |||||||
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OHSU Layton Aging and Alzheimer's Disease Center Resource Report Resource Website |
OHSU Layton Aging and Alzheimer's Disease Center (RRID:SCR_008821) | topical portal, data or information resource, disease-related portal, training resource, portal | An aging and Alzheimer's disease research center that conducts studies of treatments, technologies for patient support, genetics, neuroimaging, and pathology. The Center's clinical research focuses on understanding differing rates of progression and cognitive decline as compared to optimal cognitive health in the elderly and are currently studying methods of gauging the progression of Alzheimer’s disease through research in genetics, neuroimaging, and cerebrospinal fluid biomarkers. Clinical trials performed at the Center include drugs targeted to ameliorate the symptoms of memory failure and slow the progression of disease. | alzheimer's disease, late adult human, dementia, brain, oregon, training resource, aging, clinical research, clinical trial |
has parent organization: Oregon Health and Science University; Oregon; USA is parent organization of: Layton Center Clinical Data Resources is parent organization of: Layton Center NeuroImaging Laboratory is parent organization of: Layton Center Biomarkers and Genetics is parent organization of: Layton Aging and Alzheimers Disease Center Education Core is parent organization of: Layton Alzheimers Disease Center Biomarkers and Genetics Core Lab is parent organization of: Layton Alzheimers Disease Center Clinical Core |
Aging, Alzheimer's disease | NIA | Public | nlx_144445 | SCR_008821 | Layton Aging and Alzheimers Disease Center, Layton Center, OHSU Layton Center, C. Rex and Ruth H. Layton Aging and Alzheimer’s Disease Center | 2026-08-13 09:28:00 | 0 | ||||||
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University of Pennslyvania Brain Bank Resource Report Resource Website 1+ mentions |
University of Pennslyvania Brain Bank (RRID:SCR_008820) | material resource, brain bank, tissue bank, biomaterial supply resource | A brain and tissue bank that contains human brain samples from patients with Alzheimer's disease (AD), Parkinson's disease (PD) and other related neurodegenerative dementias and movement disorders. This brain bank serves as a resource for scientists and researchers, providing access to tissue samples for further research. While priority is given to University of Pennsylvania researchers, this bank will provide requests to researchers not associated with the University of Pennsylvania. This tissue bank accepts donations from those seeing a University of Pennsylvania physician or collaborator. | nervous system tissue, brain tissue, spinal cord, brain, tissue, dna, rna, slide, paraffin, alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis, frontotemporal disease, aging related neurodegenerative disorder, mild cognitive impairment, dementia, late adult human, clinical data, neurodegenerative disease |
is listed by: One Mind Biospecimen Bank Listing has parent organization: University of Pennsylvania Center for Neurodegenerative Disease Research has parent organization: Penn Alzheimer's Disease Center |
Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, Frontetemporal disease, Aging related neurodegenerative disorder, Mild Cognitive Impairment, Dementia, Aging | NIH | Public, For scientists and researchers, Priority is given to researchers working on NIH-funded multi-component projects being conducted at Penn or in collaboration with researchers at Penn, Requests from outside researchers and scientists are honored | nlx_144493 | http://www.med.upenn.edu/cndr/donatingbrain.shtml | SCR_008820 | Tissue Donation and the Penn Brain Bank, University of Pennsylvania Brain Bank, Tissue Donation the Penn Brain Bank, Penn Brain Bank | 2026-08-13 09:27:56 | 1 | |||||
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Rutgers University Quantitative Neuroscience Laboratory Resource Report Resource Website 1+ mentions |
Rutgers University Quantitative Neuroscience Laboratory (RRID:SCR_008541) | data or information resource, organization portal, laboratory portal, database, portal | THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. The brain is made of billions of neurons, which together form the world''s most powerful information-processing machine. Despite decades of research, the fundamental principle by which these cells work together is still unknown. Many theories for brain function have been proposed over the last century. But only in the last few years has it become possible to record simultaneously from large enough numbers of neurons to put these theories to the test experimentally. This is an unprecedented opportunity, but it opens up a new question: how do we go from the gigabytes of experimental data that we now have, to concise conclusions about the function of the brain? The data processing methods traditionally used in neuroscience are not sophisticated enough to exploit this new flood of information. Fortunately, modern statistics and machine learning theory is making great strides in precisely the type of techniques needed to process these large multivariate databases. By applying these methods to neuronal data, we can now test long-standing hypotheses about brain function. The Cell Assembly The main focus of our research is an experimental search for cell assemblies. Before describing what a cell assembly is, it will be useful to describe what it is not. The brain is often thought of as a feed-forward system. In this scheme, sensory information is processed by successive levels of cortical analyzers, each of which transforms the results of previous levels, until sensory information is in a suitable form to guide the animals behavior. In support of this idea, the pattern of connections in the cortex does appear to respect a hierarchical organization, with the output of low-level areas corresponding to a single sensory modality being integrated into high-level multi-modal areas. Responses in higher-level sensory areas appear to have more complex responses to sensory stimuli, in agreement with increased abstraction as the hierarchy is traversed. However, there are several levels at which this feed-forward picture is incomplete. At the circuit diagram level, there more connections projecting across and down the hierarchy, than there are feed-forward projections. What''s more, if information were processed in a strictly feed-forward manner, one would expect a neuron to respond identically to repeated presentations of the same sensory stimulus. Although this is a fairly good approximation in primary sensory areas of cortex, in high-level structures responses are often more variable than expected from strict sensory control. Finally, although feed-forward processing can describe how an animal could perform simple stimulus-response behaviors, it cannot explain more complex top-down behaviors such as memory or thought. An alternative point of view, put forward over 50 years ago by Canadian psychologist Donald Hebb, holds that recurrent and feedback connections play an essential role in brain function. The principal actor in this view is the cell assembly, an anatomically distributed subset of neurons, amongst which mutually excitatory connections have been strengthened by repeated co-activation, allowing the assembly to later maintain its activity through reverberation without direct sensory stimulation. This theory allows for sensory-response behavior, and also behavior resulting purely from internally generated cognitive activity, by the sequential activation of a series of assemblies, leading in turn to the production of motion. In our research, we search for signatures of assembly activity in simultaneous recordings from multiple neurons, and aim to characterize the properties of assembly activity in ways not possible from theory alone. Software for Automatic Clustering KlustaKwik is a program developed in the lab for automatic cluster analysis, specifically designed to run fast on large data sets. In order facilitate open-source development, it is now located at klustakwik.sourceforge.net. This study was supported by NIH grants MH073245 and DC009947; NSF grant SBE-0542013 to the Temporal Dynamics of Learning Center, an NSF Science of Learning Center; a National Institute on Deafness and Other Communication Disorders, NIH, grant DC-005787-01A1; and a Spanish grant FIS 2006-09294. K.D.H. is an Alfred P. Sloan fellow. We would like to dedicate this work to the memory of D. J. Amit. | THIS RESOURCE IS NO LONGER IN SERVICE | nif-0000-31389 | SCR_008541 | Rutgers, Quantitative Neuroscience Laboratory | 2026-08-13 09:27:55 | 8 | ||||||||||
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Clinical Research Study Investigators Toolbox Resource Report Resource Website |
Clinical Research Study Investigators Toolbox (RRID:SCR_008815) | NIA Clinical Research Toolbox | topical portal, data or information resource, narrative resource, standard specification, portal | The purpose of the NIA Clinical Research Toolbox is to provide a Web-based information repository for investigators and staff involved in clinical research. The Toolbox contains templates, sample forms, guidelines, regulations and information materials to assist investigators in the development and conduct of high quality clinical research studies. | clinical research, adverse event, monitor, safety, informed consent, clinical research term, clinical | Aging | nlx_144419 | SCR_008815 | NIA Clinical Research Study Investigators Toolbox, Clinical Research Study Investigator''s Toolbox, NIA Clinical Research Study Investigator''s Toolbox | 2026-08-13 09:27:59 | 0 |
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